Do people find their neuropathy symptoms get worse as the day goes on?
 

Hi

I was wondering if people with peripheral neuropathy find they are better in the morning, and worse as the day goes by? In the morning I am kind of OKish, but by evening my knees burn/ tingle a lot, and my arms are more sensitive.

Thanks,

Chris

the drop in temperature might explain the progression, but it doesnt explain how it happens. It depends on the cause of the PN if found, People on this board have extremes on both day or night. When mine started it basically was the same throughout the day. i recently started getting pains in areas, where the pn used to be.

yes I do
 

I have nerve damage in my feet and they for sure get worse as the day progresses

Yes, and they are worst during the night.

Hugs, ElaineD

Miine are worse as the day progresses
 

And usually more consistently noticeable beginning around 3pm. It continues until I go to bed. It calms down when I'm sleeping (except on nights that it keeps me up.) I don't know the explanation but I think I saw one somewhere in another post that made sense.

My pain begins at sundown...gone by morning. I've searched for an explanation for this and read it may have something to do with circadian rhythms (not much of an explanation).

Yeah that is about the same as me. I don't really notice it at night much, but gets worse as the afternoon progresses and evening too. I don't know why.

One of the reasons inflammatory arthritis was ruled out seems to be I don't really get the morning stiffness.

I am not sure of the exact relationship but I have also heard that cortisol level issues can be a contributor to this as well. Are they actually good or bad? test were done on rats but still, This is interesting food for thought...

http://neurotalk.psychcentral.com/sh...d.php?t=160825

If I am going to flare, it will be after 10pm. Lots of burning then.

I seem to be the opposite. My pain is so excruciating in the morning that I have to get out of bed as soon as I wake up. The pain shoots and stings through out my shoulders, hands, neck and down from my sacrum through thighs, calves, and feet. I get my hot pack on my neck which allows me to start using my arms and a warm drink, and around 11 am I start to improve. I have pain and symptoms throughout the whole day, but not enough to need to take anything. It seems to worsen again around 7 and I have to be in bed by 9 or the autonomic stuff gets very bad. If I'm lucky I make it through the night. On some nights it is so bad that I can't fall asleep or the symptoms wake me up, I have meds that help me cope through the episode.

Thanks Patrick!
 

I'm trying to figure this whole cortisol thing out myself right now.

Yes, I find that the more fatigued I am the worse my symptoms are.

Many people--
 

--with neuropathy (though certainly not all) report this pattern: symptoms that tend to worsen as the day goes on, and particularly at night.

There have been a lot of theories as to why, ranging from the circadian/hormonal/cortisol idea to the "lack of interference" idea--during the day, there are many other stimuli, such as mechanical touch and proprioceptive, to interfere with pain signals, which are generally the ones that are most slowly transmitted, but as activity level diminishes these pain signals from smaller fibers are less interfered with and become more noticeable.

Also, those whose neuropathy has an ischemic or circulatory component or compromise (diabetic, autoimmune/connective tissue) often experience this and it is thought that our circulation is more even earlier in the day after a long period of inactivity/recumbence, and worsens with activity and being upright over the course of the day.

Still, I don't think any researchers or anyone else are yet quite sure why so many experience this, and why not all sufferer do.