? to you here with psoriasis
 

I am presently on Taclonex which my copy is $75. It doens't seem to be helping. I have tried Dovonex, Clobetasol, Soriataine and nothing seems to help. My main problem is my scalp. What do you all use? I know they have some miracle drugs out there but they can cause neurological problems. My feeling right now is that if they cause it, so what, I already have it. Would it make my MS significantly worse? Has anyone tried laser therapy?

bumpity bump!

I have plantar palmar pustural psoriasis, so things may be different, it's harder to treat. I've been through the battery of trying this and that, which didn't work. The only thing I found to help was when I was on hormone replacement, it totally went away, and has never been as bad since. (it's been ten years since I stopped the hormones).

For what it's worth.
Pat

bumping back up for you!

Betamethasone Dipropionate seems to be keeping my Psoriasis in check. I, like you, have tried EVERYTHING to no avail. Doc gave me this cream and the Pso. I had on my foot is gone. It's still on the palms of my hands, but not as bad.

Ask Your Doc about it, Doydie. Who knows, it may work for you, too.:)

I have it very mildly on my scalp. And I have signs of it on my ankles and around my knees. The scalp gets a little itchy some times but it I leave it alone it seems to be OK.

Mine seems to come and go and I don't use any medication. I try to get plenty of rest and to eat well.

My mother had it worse than I and I wonder if it is not hereditary. Hope you find something that works for you :). I realise that medication is sometimes necessary.

The last time I saw the dermatologist I asked him what reatments were available besides medicine. That's when he told me that they do use the laser therapy but he didn't tell me anything about it. I told him that since the lesions are where it doesn't show, I'm not a vain person and it doesn't matter. Well it's now on my ankles, behind my knees and below, all over and I mean all over my scalp, bad lesion on my low back and areas on my back that I can't reach to put medicine on. The worst now is in my genitalia area, front, back and in between! Yuck and I don't want him to look at it. So it needs taken care of.

Here is a link to an article talking about how the Mayo Clinic has new information about treating psoriasis on its website. Maybe it will help you.

http://www.medicalnewstoday.com/articles/98481.php

gmi

Thank for the web site. You can find almost anything there.

Well I asked my neuro today about what would happen to my MS if I did take one of those new drugs. She looked it up in the PDR and saw how it reacted on the cellular level and said it would not be good for someone With MS. So, back to the drawing board.

I had a terrible episode with it on the palm of my hand about a year before I was dx with MS. I could not figure out what was causing it - and nothing helped. I finally went to the dermatologist and he said it was "contact dermatitis". He gave me Temovate cream and I used it for several months. It helped my immediate symptoms but did not make it go away. It finally cleared up on it's own and I've never had it again. About six months later I was dx with MS.

I have had psorisis since the birth of my son in 1978, mostly my knees, elbows, shins. These areas are very tough to treat because it has been there so long. I noticed about 2 years ago that every time I got a new cut, or scratch after the healing there would be a lesion of psoriasis. These areas however are easy to treat with just about any ointment the Dr. has given me over the years. The only thing that has truly helped is when I am put on prednisone when my aysthma flares up. Then everything clears up unfortunetly it is temporary:( I did come across something in walgreens called SKIN ZINC it is a 2 part system a spray and then a lotion and when I use it the way your supposed to it really helps a lot:)

:hug:I am on Elidel and Mometizone (sp?) creme. the mome cream ROCKS! witin 24 hours its GONE! the elidel is a maintence stuff. I have seen a dramatic change since using it. its a very strong steroid cream, and they warn you about all the side effects, but WOW I was ready to rip my ears off! The skin behind my ears was cracked open! it was painful.

I hope you find what works. :hug:

go to pubmed and check out "vitamin d psoriasis"

I'm almosy afraid to brag, but my psoriasis has been under control for months now. I use a concoction of vasaline and Ponds lotion.

I have used everything I can think of, but it always came back, stronger than ever. All of a sudden, I had a memory of when I was about 7/8 and had Psorisis on my knees. I got into my Mom Old pink Ponds and vasaline....it worked..:D:cool:

That's my story and I'm sticking to it. :)

CURCUMIN (Turmeric) ????
 

Try some CURCUMIN (Turmeric) it cures PSORIASAS, FUNGUS in The toes, raises HDL in the blood, cures Arthritis and MS. It worked for me.

Please do not shovel in RAW Tumeric down the gullet... IT DOES NOT GET ABSORBED in it's RAW form.!!!!!!! A little Tumeric on your food will obviously not work either.

You will need to try SOMETHING LIKE Life Extension's Product "Super Bio-Curcumin". It has my toenails and toes looking great and my Psoriasas is almost completely gone. I took it for my MS and was pleasantly surprised by these "side-effects". I am most grateful for the absence of pain in my joints and fingers.

http://www.lef.org/Vitamins-Suppleme...-Curcumin.html

Arch Physiol Biochem. 2008 Apr;114(2):127-49.

Role of curcumin in health and disease.

Pari L, Tewas D, Eckel J.

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. In recent years, considerable interest has been focused on curcumin due to its use to treat a wide variety of disorders without any side effects. It is one of the major curcuminoids of turmeric, which impart its characteristic yellow colour. It was used in ancient times on the Indian subcontinent to treat various illnesses such as rheumatism, body ache, skin diseases, intestinal worms, diarrhoea, intermittent fevers, hepatic disorders, biliousness, urinary discharges, dyspepsia, inflammations, constipation, leukoderma, amenorrhea, and colic.

Curcumin has the potential to treat a wide variety of inflammatory diseases including cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer's disease, psoriasis, etc, through modulation of numerous molecular targets. This article reviews the use of curcumin for the chemoprevention and treatment of various diseases.

PMID: 18484280 [PubMed - indexed for MEDLINE]




jackD

Do you take just one capsule a day? I've been taking this supplement now for about two weeks. I'm sure that's not enough time to see any improvement. My dosage is a 500 mg capsule once daily.

While I'm not sure that it "cures" MS what I've read about it as a nutritional supplement sounds promising.

PLEASE PLEASE PLEASE TELL ME EXACTELY WHAT YOU ARE TAKING.

IF YOU ARE TAKING PLAIN RAW CURCUMIN (Turmeric) you can swallow the whole bottle and get NO EFFECT besides some funky colored poo poos.

jackD
.
Planta Med. 1998 May;64(4):353-6.

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.

Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS.

Department of Pharmacology, St. John's Medical College, Bangalore, India.

"]The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg increased the serum concentration of curcumin for a short period of 1-2 h post drug. Time to maximum was significantly increased (P < 0.02) while elimination half life and clearance significantly decreased (P < 0.02), and the bioavailability was increased by 154%. On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.

PMID: 9619120 [PubMed - indexed for MEDLINE]

I'm taking Curcu-Gel Ultra (500 mg). The bottle says "500 mg Curcuminoids Complex with Volatile
Oils of Tumeric Rhizome (Curcuma longa)". It's a softgel (it's huge!) and the directions say to take 1 a day.

Great!
 

GREAT! You are taking an excellent form of CURCUMIN! I found it takes about 30 days before a major change was noted.

http://www.epic4health.com/cuul500mgena.html

The addition of the root extract BCM-95™ gives it enhanced bioavailability and sustained retention time in the body thus it can have a true therapeutic effect.

I might switch to this brand myself because it contains more Curcumin than mine and it is cheaper.

jackD

Just some things that have helped me. I use cetaphil cleanser to wash my body, glaxal base or Vaseline petroleum jelly as moisturizers. Organic virgin coconut oil for body and scalp, and I have even washed my scalp with olive oil natural bar soap. I hope this helps you.

pycnogenol cures psoriasis at the genic level
 

Pine Bark extract pycnogenol is VERY effective at eliminating psoriasis. It worked very well for me and my brother. My last long stay in hospital (two months) resulted in the psoriasis coming back with a vengeance. After 30 days back on pycnogenol (100 mg twice a day) my psoriasis was all gone. Minimum effective dose is 150 mg.

This stuff is GREAT for MS. (lowers MMP-9s and Gamma Interferon levels)

jackD





1. Phytother Res. 2001 Feb;15(1):76-8.

From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited.

Rihn B1, Saliou C, Bottin MC, Keith G, Packer L.
Author information:
1Membrane Bioenergetics Group, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.

Abstract
The effect of French maritime pine bark extract (PBE) on the gene expression profile of HaCaT human keratinocytes was studied using high density filter arrays. The expression profile of both control and PBE-treated cells was determined.

Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses.

Copyright 2001 John Wiley & Sons, Ltd.

PMID: 11180529 [PubMed - indexed for MEDLINE]



Free Radic Biol Med. 2000 Jan 15;28(2):219-27.

Pine bark extract pycnogenol downregulates IFN-gamma-induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression.
Bito T1, Roy S, Sen CK, Packer L.
Author information:
1Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.

Abstract
Expression of intercellular adhesion molecule-1 (ICAM-1) is necessary for leukocyte/keratinocyte interactions. Upregulation of ICAM-1 expression in keratinocytes has been observed in several inflammatory dermatoses, such as psoriasis, atopic dermatitis, and lupus erythematosus. Inflammatory cytokines, such as interferon-gamma (IFN-gamma), upregulate ICAM-1 expression in keratinocytes.

Because of potent antioxidant and anti-inflammatory properties of the French maritime pine bark extract, Pycnogenol (Horphag Research, Geneva, Switzerland), its effects were investigated on the interaction of T cells with keratinocytes after activation with IFN-gamma and the molecular mechanisms involved in such interactions.

Studies were performed using a human keratinocyte cell line, HaCaT. Cell adhesion in the presence of IFN-gamma was studied using a coculture assay. Treatment of HaCaT cells with 20 U/ml IFN-gamma for 24 h markedly induced adherence of Jurkat T cells to HaCaT cells. PYC pretreatment (50 microg/ml, 12 h) significantly inhibited IFN-gamma induced adherence of T cells to HaCaT cells (p < .01). ICAM-1 plays a major role in the IFN-gamma-induced adherence of T cells to keratinocytes.

Thus, the effect of PYC on IFN-gamma-induced ICAM-1 expression was investigated as well. Pretreatment of HaCaT cells with PYC significantly inhibited IFN-gamma-induced expression of ICAM-1 expression in HaCaT cells. The downregulation of inducible ICAM-1 expression by PYC was both dose and time dependent. A 50 microg/ml dose of PYC and a 12 h pretreatment time (i.e., before activation with IFN-gamma) provided maximal (approximately 70%) inhibition of inducible ICAM-1 expression in HaCaT cells. Gamma-activated sequence present on the ICAM-1 gene confers IFN-gamma responsiveness in selected cells of epithelial origin (e.g., keratinocytes) that are known to express ICAM-1 on activation with IFN-gamma. Gel-shift assays revealed that PYC inhibits IFN-gamma-mediated activation of Stat1, thus suggesting a transcriptional regulation of inducible ICAM-1 expression by PYC.

These results indicate the therapeutic potential of PYC in patients with inflammatory skin disorders.
PMID: 11281289 [PubMed - indexed for MEDLINE]