GIFT15 -- Hope on the horizon for an MS cure?
 

http://www.statesman.com/health/cont...c-/629953.html

Well, they can cure it in mice, anyway.

They've taken two proteins that, individually, stimulate the immune system. But when they fuse them together in the lab, sprinkle them on B-cells and give them back intravenously, they suppress it!

The treatment was effective with a single dose with no apparent side effects. :)

HOPE! HOPE! HOPE! Wouldn't this be wonderful if it turned out to be the cure!! It really would be a "GIFT". HURRY PLEASE!! Thanks for posting this, Rochelle! :)

This would be wonderful if they could find a way to make it a reality for humans. Thanks for sharing the article with us, Twink!

I have one question. I've always wondered about this when they say "mice with MS". How do they know the mouse has MS? Do they do an MRI? An LP? It's a dx that takes so long for some people - what with eliminating dozens of other conditions and all - how do they dx MS in mice? What's the protocol?

My cog fog is brutal these days so the answer may be very obvious.....ya'll don't laugh at me if it is! :o :rolleyes:

Fan bloody tastic. This sounds very promising.

and I'm stumped too; how do they know the mouse has ms????

http://timesofindia.indiatimes.com/l...ow/4889885.cms

I think (THINK) the give rats and Mice not MS, but a disease (stating with e??) and from knowledge they gave it to them and resulting behaviors work on it. It's not MS, mice aren't humans so us MSers don't alway benefit as benefits of cure not transferable. Hope we do this time.

What you are referring to is called Experimental Allergic Encephalomyelitis.(EAE) It is a disease that is induced into mice and although it mimics MS in humans it is VERY different. They have been using the EAE mouse model for decades in MS research and for decades there has not been any treatments that have worked in that poor mouse that have eventually been beneficial to human MS patients.

Back in the mid 90's, my wife was enrolled in a MS clinical trial for a drug that stopped and reversed MS in the "mouse". After about a year into the trial, the high dose of the drug caused a fatal heart attack in a patient and the trial was quickly halted and abandoned.

The time span for a discovery of this nature and when it may be trialled on humans is about 10 years!

Harry

They often "cure" mice., but never me. Ah, to be a mouse. Mice and rats have much shorter life-spans so testing for long-term side effects can only be done with humans.

I am hoping...for sure
 

when I heard the news last night - i was sooooooo excited. I hope we could be a support for eachother - since it seems we are all going through the samething - BUT WE COULD ALWAYS HOPE!!! If this does work - I am proud to be a part of that hospital who discovered this wonder GIFT15.

Hurray - The Jewish General Hospital TEAM - truly Appreciated!!! Keep up the good work!!!

:)

So true, Kicker...damn mices..:rolleyes:

Are they talking, suppressing the IS again? I hate when they do that..:confused:

It's EAE
 

A granulocyte-macrophage colony–stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties

The difficulty in magazine articles is the folks writting them often don't know what they are writing about. Just the idea that someone had figured out how to give a mouse MS would be ground breaking. In this case it's EAE again and I can't count the number of times science has cured the mouse of EAE. Ken

The reason we have so many "cures" for mice now is because the researchers know what causes EAE. These research mice are "given" the disease, thereby making it much easier to cure EAE, which is not MS anyway.

Once the cause of MS is known there should be a lot of cures for people too.

gmi

I agree. First they have to find the cause, then the cure will come.

Rochelle,
Thanks for posting this article. How I wish things would move quicker!:hug:

I think one of the problems is that there are causes

makes it kinda tough if you're trying to nail down one outcomewith a low P-value.

Squeak, squeak. If I paint on whiskers and put my tail on (yeah, already got one from a Halloween) think I can fool them???

Good news
 

Usually when they put something on the news they usually have an idea, I just can't help but think about the movie I am legend when they talk about curing things. Nothing would please me more than be done with this crap and the ignorance that has to be dealt with. I don't know if this is true but I was told that one of the researchers had given some to one of his buddies suffering from MS when he saw the results of the mouse

Just remember that after they cure you, they will chop off your head to have a looksee at how it happened.

gmi

Hey there mitypines........Have you heard about any results from the person who received the "GIFT" (assuming it was true)? Please, please, please, let this be the ONE we've all been waiting for!!! Thanks mp........:)

Well, when you put it like that!!!

My niece (MIT grad) worked summers at Stem Cell place. Thought about asking her to steal some but realized I didn't know how to use!!

You're right, kicker, there may be different options in dosage, times, etc., not to mention side effects with "unknowns". I'm wondering when they say possible CURE, do they mean just stopping the disease where it is or correcting the damage already done?? Guess we're still in the dark when it comes to obliterating this lousy disease.

By the way, I see you're in MD -- are you on the Eastern Shore by any chance? Have a friend who lives in Crystal Beach. Take care! :)

[QUOTE=Judy;553857]You're right, kicker, there may be different options in dosage, times, etc., not to mention side effects with "unknowns". I'm wondering when they say possible CURE, do they mean just stopping the disease where it is or correcting the damage already done?? Guess we're still in the dark when it comes to obliterating this lousy disease.

QUOTE]

I may have interpreted that wrong. I think what it meant/said was a "permanent remission" of symptoms.

[QUOTE=Twinkletoes;553861]The only way a total cure will happen in the near future is through head transplants. I have seen nothing that talks about neuro repair for those of us with holes in our heads.

gmi

is now a good time to start a thread about this ....... :winky:

[QUOTE=gonnamakeit;554172]GMI,
Now you're just talking silly!!! 8-)

Or is that Twink talking silly? I'm so confused.

Nope. That was gmi.