A natural product with promise in treating PD
 

A recent report shows that squalamine (made by a kind of shark) can block α-synuclein aggregation as well as its toxicity in a human cell line and in a worm model.

http://www.pnas.org/content/114/6/E1009.full.pdf

Hi kiwi33,

A thread on this topic was started last month (same research paper):

https://www.neurotalk.org/parkinson-...odel-worm.html

Sorry jefferyn.

The paper in its final form is in the latest issue of PNAS (Volume 114(6), 7 February).

I got my regular automatic email advisory of PNAS issues this morning and it did not occur to me to check if somebody might have noticed it in pre-publication form.

No worries, kiwi33.

The other thread didn't generate any discussion, but there was some discussion in a similar thread elsewhere.

Summary of the discussion:
- may be more work needed regarding possible uncertainty in degree of penetration of the blood-brain barrier;
- available supplement (Squalamax) contains a very small amount of squalamine;
- overall: potentially important development but still some way to go.

From the SoPD blog, an update on Squalamine.

Squalamine begets Trodusquemine | The Science of Parkinson's

Fyi
 

Since it will take forever to clinical trial these, anyone who wants to take the risk and self dose maybe can find a source to buy trodusquemine. Somewhere in these articles it mentions that squalamine does not cross the b/b.



Squalamine and Squalamine Supplement


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