NeuroTalk Support Groups - Drug Induced Lupus:

Drug induced lupus, is similar to autoimmune lupus, but not as severe. It can have inflammatory pain in the joints, and rashes on the body, and in general be painful and serious.

Here is a link:
http://www.lupus.org/webmodules/weba...=377&zoneid=17

The list given here does not include every potential cause. As data is reported slowly, the list changes to reflect that.

This article from 2001 reports DIL from ACE inhibitors:

Quote:

South Med J. 2001 Nov;94(11):1122-3.
Antinuclear antibody-negative, drug-induced lupus caused by lisinopril.
Carter JD, Valeriano-Marcet J, Kanik KS, Vasey FB.
Source

Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612, USA.
Abstract

The clinical symptoms of drug-induced lupus (DIL) are similar to those of idiopathic systemic lupus erythematosus. The literature indicates that in patients with DIL, sera generally contain antinuclear antibodies (ANAs); however, ANA-negative DIL has been reported. The list of medications implicated as etiologic agents in DIL continues to grow. This list includes two different types of angiotensin-converting enzyme inhibitors--captopril and enalapril. We report the first case of DIL caused by lisinopril. Our patient had negative results on ANA testing and had histone antibodies (IgG anti-[H2A-H2B]-DNA) mirroring the disease course. Antibodies to the (H2A-H2B)-DNA complex are seen in more than 90% of patients with active DIL, excluding those with DIL due to hydralazine. Thus, it is important to recognize the clinical significance of IgG anti-(H2A-H2B)-DNA antibodies and that negative ANA test results do not preclude the diagnosis of DIL.

PMID:
11780682
[PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/11780682

The only real treatment is removal of the offending drug.

30+yrs ago I had a drug induced lupus from Hydralazine, which I had to take for my pregnancy hypertension.

Recently I've had a second attack involving my long term blood pressure medication, lisinopril.

So I am posting this here, for those who may have side effects from any medications they may be taking, causing lupus-like symptoms and having a negative ANA autoimmune panel in testing.

People vary in their genetic composition, and hence ability to tolerate drugs in general. So don't underestimate any therapy you are having, which suddenly develops into a lupus like syndrome. The drug lists available today are not complete, and it can take many years to identify new culprits.

Bookmark the Lupus Foundations address, so you can consult it in the future.