OT - Considering the benefits of the Mediterranean diet for brain health
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Soccertese, thanks for raising this topic.
Based on epidemiological evidence Gao et al. [1] put the relative risk of developing PD, for the quintile most strongly on a prudent (Mediterranean) diet as 0.78. I think it may be interesting to investigate whether there are any linkages between the Mediterranian diet and alpha-synuclein. Caruana and Vassallo write [2] "Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent." "several polyphenols counteract the cytotoxic properties of alpha-synuclein aggregates directly in a cellular context" "Polyphenolic compounds are naturally-present constituents of a wide variety of fruits, vegetables, food products and beverages derived from plants such as olive oil, tea, and red wine." Tag johnt:alpha-synuclein [1] "Prospective study of dietary pattern and risk of Parkinson disease" Xiang Gao, Honglei Chen, Teresa T Fung, Giancarlo Logroscino, Michael A Schwarzschild, Frank B Hu, and Alberto Ascherio The American Journal of Clinical Nutrition, 2007 http://ajcn.nutrition.org/content/86/5/1486.full [2] "The potenial role of dietary polyphenols in Parkinson's disease" Caruana M., Vassallo N. Malta Medical Journal, 23.03, 2011 http://www.um.edu.mt/umms/mmj/PDF/334.pdf John |
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