Who would have thunk it!
 

The effects of laxatives may provide new clues concerning Parkinson's disease

"In a recent retrospective analysis, investigators discovered that the year-on-year increase in rigidity found in Parkinson's disease flattened off with the regular use of laxatives to manage constipation."

This paper [1], full version, is by some of the same researchers that our late member John Hutton worked with.

They report:
"5.5% per year increase in flexor rigidity before maintenance laxatives were introduced, and plateauing after."

I suffer badly from constipation and feel a marked increase in performance after defecating. I've put this down to this event freeing up the absorption site for levodopa in the upper colon.

This paper, however, considers a wider range of possible mechanisms as to why constipation can affect PD, including alpha-synuclein misfolding.

The perceived importance of the gut in the pathogenesis of PD seems to be increasing.

It is also interesting that they used objective measuring techniques, rather than relying on UPDRS.

Reference:
[1] "Quantifying rigidity of Parkinson’s disease in
relation to laxative treatment: a service evaluation"
Aisha Augustin et al.
BJCP, April 2016
http://onlinelibrary.wiley.com/doi/1...bcp.12967/epdf

John

Would increasing transit time for a non-constipated PD patient flat line rigidity as well?

I assume it would since it would increase gastrointestinal transit time, regardless.

Colace and Senekot are part of my "keep things moving" but not daily, just as needed.

It will be interesting to learn more about gut and mis-folded proteins.