information source, website of mds DR. ENRICO FAZZINI
 

i check this site periodically for updates. can't vouch for how good a mds he is but he certainly has interesting opinions, especially on the superiority of brand name mirapex xl and requp xl, much less side affects than generic. unfortunately they aren't cheap.
http://www.theparkinsonsdoctor.com/

What nutritional supplements do I recommend? CoQ10 (1200 mg/day), NADH (20 mg/day), Vitamin D3, creatine and selenium as well as B vitamins and folic acid.

i'd take that with a grain of salt, coq10 at 1200mg was initially thought to slow progression but subsequent trial with 2400mg showed no benefit. creatine also doesn't slow progression but might have other benefits.

it's not about slowing progression. COq10, Ubiquinol, Nadh, Creatine power up your mitocondria and give you energy to fight fatigue and power through your day.

so your're saying take 1200mg of coq10?
i tried the 1200mg coq10 for a few months when it cost $200 for a months supply after the first clinical trial came out , and nadh for a month, felt no benefit.


http://www.pdf.org/en/science_news/r.../pr_1398181054

*copyright material edited out*

so your're saying take 1200mg of coq10?

The doctor on the website you posted above recommends that.

I stand by my statement above.

Hi Badboy,
Just lost a posting I wrote re your drug regime.
Anyway wanted to let you know how excited I am to read that you take NADH.
My son does post doc research on NAD which I assume to be connected to NADH and he has me taking that each day and that he and his colleagues are being shown very promising results with mice!
Am not particularly computer literate hence my certainty that they're the same or similar but think the 2 are linked.
I think though can't prove after taking the supplement for approx. 8 months now that Im a little better and having been to GP this morning for FBC results I can say my glucose and liver function tests which were a little on the dodgy side a yr ago are now within normal limits etc.
Soccertese thanks for the link to Dr Fazzini he seems very knowledgeable re PD.

Yes, NAD is the oxidised form of NADH.

NAD and NADH are essential for all human cells - they play a key role in production of ATP, which is the "energy currency" that all cells need.

From a biochemical perspective, I can't think of circumstances in which somebody could be deficient in NAD but not in NADH.

Hi.

My neurologist was few weeks ago in Switzerland, for a Congress, and he told me the community is also discussing N-acetylcysteine - a gluthation precursor - as a adjuvant therapy. I take it on my own, 1,200 mg daily, although apparently best dose in a recent study is 70 mg/kg.

Gluthation is an endogenous antioxidant.

Someone else already posted this link before but in case you need it, I copy link for you:

Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease

http://www.ncbi.nlm.nih.gov/pubmed/25765302

Lobo

THERE's a clinical trial starting testing nasal glutathione at 2 different dosings.

i'm a little skeptical but we'll know soon if glutathione helps reduce symptoms.
it's in seattle at bastyr u.

Study Purpose:

Glutathione is an important nutrient for brain function and loss of glutathione has been implicated in Parkinson's disease. Glutathione is an antioxidant made in the body out of three amino acids, the nutrients that make up protein. This study will determine whether administration of either dose of glutathione, as a nasal spray, improves PD symptoms over time in a population of individuals with Parkinson's disease (PD).