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- Gluten Sensitivity / Celiac Disease (https://www.neurotalk.org/gluten-sensitivity-celiac-disease/)

- - HLA Testing (https://www.neurotalk.org/gluten-sensitivity-celiac-disease/5767-hla-testing.html)

When your doctors ordered your gene testing for the HLA, did they ask for only a specific test or did they ask for HLA-A, B, C, DR, DQ, DP?

I've had only three done:
B27 negative
DQ 2 positive
DQ 8 negative

I know that different HLA genes can create/affect different diseases. DQ & DR are with Celiac. I'm in the process of getting information about which gene affects which disease.

Thanks, Just curious & learning.

which gene affects which disease

I found some information:

http://www.questdiagnostics.com/bran...u_gen/faq.html

http://www.cdc.gov/ncidod/eid/vol3no1/singh.htm

http://www.thyroidmanager.org/Chapter7/7-text.htm
refer to part 3. Antigen Presentation On MHC Molecules, complex but does have good info

http://www.jci.org/cgi/content/full/116/8/2226
specific to Celiac

http://www.uchsc.edu/misc/diabetes/oxch8.html
I found this interesting because I can now go to my mother w/proof that her addison's disease is linked to my Celiac by the HLA DQ 2

http://www.endotext.org/diabetes/dia.../diabetes5.htm
Interesting notation in the link:

Quote:

When an individual presents with type 1A diabetes it indicates that they and their relatives have an increased risk of having or developing a series of autoimmune disorders(11). Celiac disease, hypothyroidism, hyperthyroidism, Addison’s disease and pernicious anemia are some of the most prominent associated diseases. For example approximately 1/20 patients with type 1 diabetes have celiac disease(13;14). Most of these patients are asymptomatic and the disorder is only discovered if anti-transglutaminase autoantibodies are measured and individuals with positive antibodies biopsied. In that the therapy for celiac disease, namely gluten avoidance, is highly effective, at the Barbara Davis Center we routinely screen all type 1 diabetic patients. We also screen for thyroid disease and for Addison’s disease (21-hydroxylase autoantibodies)(15).

http://www.annals.org/cgi/reprint/142/4/289.pdf
specific to celiac - very good

Quote:

Originally Posted by klasyjo (Post 35733)

I know that different HLA genes can create/affect different diseases. DQ & DR are with Celiac. I'm in the process of getting information about which gene affects which disease.

Thanks, Just curious & learning.

I would love more info on DR and celiac. My ped ordered DR for oldest instead of DQ. She's DR 4,1 and he said thats proof positive she won't develop it. All I could find was something linking DR to RA, which makes me think it might be linked after all.

He ordered DR 2, 8 specifically on the lab order and it came back with the actual results.

Quote:

Originally Posted by mistofviolets (Post 35823)

Maybe he meant to order DQ 2 & 8 instead because those are the ones most common in Celiac - 95% have DQ2. I will review and see about the DR genes though.

Here is some specific info re HLA DQ4:

HLA-DR4 Rheumatoid arthritis, Sjögren's syndrome, Giant Cell Arteritis, Lyme arthritis

http://www.arthritis.org/conditions/...ra_genetic.asp

http://www.uni-duesseldorf.de/dgfi2000/abstract/x10.htm

http://www.rheumatology.org/public/f...s/heredity.asp

I didn't find much on HLA DR1 except that it's linked with HLA DR4.

http://www.kickas.org/molecular_mimicry.shtml

HLA DR1 Cicatricial pemphigoid

Quote:

Originally Posted by klasyjo (Post 35897)

Maybe he meant to order DQ 2 & 8 instead because those are the ones most common in Celiac - 95% have DQ2. I will review and see about the DR genes though.

Thanks for the links!

I think he must have been mixed up, too. But he was adament that DR 2 and 8 were the "more specific" markers than DQ. In the office I just figured he must have access to the most current research. I wonder if thats why they recordd the specific genes, instead of just what he asked for? (I read the lab slip which said specifically DR 2 & DR8)