Articles, Abstracts and News Reports on TS
Haiqun Lin, Liliya Katsovich, Musie Ghebremichael, Diane B. Findley, Heidi Grantz, Paul J. Lombroso, Robert A. King, Heping Zhang, James F. Leckman (2007)
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder Journal of Child Psychology and Psychiatry 48 (2), 157–166. doi:10.1111/j.1469-7610.2006.01687.x http://www.blackwell-synergy.com/doi...0.2006.01687.x Quote:
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Abstract - whole genome screen
Am J Hum Genet. 2007 Feb;80(2):265-72.
Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families. Tourette Syndrome Association International Consortium for Genetics. Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (-log P = 4.42, P = 3.8 x 10(-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (-log P >2.0) of additional susceptibility loci for TD. PMID: 17304708 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum |
Abstract - Dopaminergic dysfunction in frontal lobe
J Neurol Sci. 2007 Mar 2; [Epub ahead of print]
Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis. Yoon DY, Gause CD, Leckman JF, Singer HS. Department of Neurology, Johns Hopkins University School of Medicine, Harriett Lane Outpatient Building, 200 N. Wolfe Street, Suite 2158, Baltimore, MD, USA. Frontal-subcortical abnormalities have been implicated in the pathophysiology of Tourette syndrome (TS). The goal of this study was to more extensively evaluate a possible underlying neurochemical abnormality in frontal cortex. Postmortem brain tissue from frontal and occipital regions (Brodmann's areas 4, 6, 9, 10, 11, 12, and 17) from three TS patients and three age-and sex-matched controls were analyzed by semiquantitative immunoblotting. Relative densities were measured for a variety of neurochemical markers including dopamine (D1, D2), serotonin (5HT-1A), and alpha-adrenergic (alpha-2A) receptors, the dopamine transporter (DAT), a monoamine terminal marker (vesicular monoamine transporter type 2, VMAT-2), and vesicular docking and release proteins (VAMP-2, synaptotagmin, SNAP-25, syntaxin, synaptophysin). Data from each TS sample, corrected for actin content, was expressed as a percentage value of its control. Results identified consistent increases of DAT and D2 receptor density in five of six frontal regions in all three TS subjects. D1 and alpha-2A receptor density were increased in a few frontal regions. These results support the hypothesis of a dopaminergic dysfunction in the frontal lobe and a likely role in the pathophysiology of TS. PMID: 17337006 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum |
Article- Discover magazine
although this article specifically deals with autism...it has much of interest and so I felt it worth posting here too related to ASD
http://discovermagazine.com/2007/apr...tart:int=0&-C= |
Genomics
http://www.sciencedirect.com/science...c57ec46e02d5e2
Genomics. 2003 Jul;82(1):1-9. Cntnap2 is disrupted in a family with gilles de la tourette syndrome and obsessive compulsive disorder Verkerk AJ, Mathews CA, Joosse M, Eussen BH, Heutink P, Oostra BA; Tourette Syndrome Association International Consortium for Genetics. _________________ http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum Eur J Hum Genet. 2007 Mar 28 Disruption of the CNTNAP2 gene in a t(7;15) translocation family without symptoms of Gilles de la Tourette syndrome. Belloso JM, Bache I, Guitart M, Caballin MR, Halgren C, Kirchhoff M, Ropers HH, Tommerup N, Tumer Z. Quote:
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Neuropsychologia. 2007 Apr 5;
Speeded processing of grammar and tool knowledge in Tourette's syndrome. Walenski M, Mostofsky SH, Ullman MT. http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum Quote:
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Quality of Life
Interesting...
J Clin Child Adolesc Psychol. 2007 Jun;36(2):217-27. Quality of Life in Youth With Tourette's Syndrome and Chronic Tic Disorder. Storch EA, Merlo LJ, Lack C, Geffken GR, Goodman WK, Murphy TK. Department of Psychiatry and Pediatrics, University of Florida. http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum Quote:
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These two are not specifically about Tourette's Syndrome but they are of interest.
The 2nd one regarding RLS is also of interest as quite a lot of people have Restless Leg Syndrome as well as their Tics or have members in their families who have RLS as well. [It fits in with the posts regarding OC behaviours or even Secondary causes of Tics or Tourettism.] So, just some things in the news of interest... http://www.sciencedaily.com/releases...0615110252.htm from Science Daily Source: Mayo Clinic Date: June 15, 2007 Researchers Use 'Genomic Pathway' To Predict Parkinson's <snipped article> Quote:
Dopaminergic Agonists Linked to Compulsions in RLS Medscape Medical News 2007 www.medscape.com/viewarticle/558519 Registration required Caroline Cassels Quote:
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Worth a read.
Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics: AHRQ Executive Summary
http://effectivehealthcare.ahrq.gov/...nal_Report.pdf Full Text pdf This is very long, but worth reading if you're interested. Just use the search feature to highlight keywords in the file e.g. Tourette's syndrome or Autism or PTSD etc.. from Medscape Medical News 07/06/2007 Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics: AHRQ Executive Summary http://www.medscape.com/viewarticle/559169_1 |
Deep Brain Stimulation
PubMed Abstract
Curr Opin Neurol. 2007 Aug;20(4):470-6. Surgery for other movement disorders: dystonia, tics. Hamani C, Moro E. Quote:
Curr Neurol Neurosci Rep. 2007 Jul;7(4):278-89. Limbic, associative, and motor territories within the targets for deep brain stimulation: potential clinical implications. Sudhyadhom A, Bova FJ, Foote KD, Rosado CA, Kirsch-Darrow L, Okun MS. Quote:
http://www.neurology.org/cgi/content/full/68/2/85 NEUROLOGY 2007;68:85 © 2007 American Academy of Neurology January 9 Highlight and Commentary Deep brain stimulation for a teen with tics? Donald L. Gilbert, MD, MS Quote:
Tourette’s syndrome and deep brain stimulation J L Houeto, C Karachi, L Mallet, B Pillon, J Yelnik, V Mesnage, M L Welter, S Navarro, A Pelissolo, P Damier, B Pidoux, D Dormont, P Cornu and Y Agid http://www.neurology.org/cgi/content...e2=tf_ipsecsha NEUROLOGY 2006;66:E12 NeuroImages Hemi tics and deep brain stimulation Catherine L. Gallagher, MD, P. Charles Garell, MD and Erwin B. Montgomery, Jr, MD http://www.touchbriefings.com/pdf/2785/tipuaziz.pdf Deep Brain Stimulation—Which Patients and When? |
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