palmitoylethanolamide : a mast cell stabilizer
 

palmitoylethanolamide

http://www.neuropathie.nu/treatment/...thic-pain.html

http://www.neuropathie.nu/patients-o...amide-nor.html

http://www.neuropathie.nu/patients-o...d-with-no.html

http://onlinelibrary.wiley.com/doi/1...07326/abstract


What do you think ?

This is what a mast cell stabilizer does:
http://en.wikipedia.org/wiki/Mast_cell_stabilizer

This chemical compound is really working on the cannibinoid receptors in the brain for pain. So calling it a mast cell stabilizer is confusing.

I reserve comment until someone comes along with their experiences.

When I searched this product, I found only one place selling and it was in Italy, and the shipping charges to here in US cost more than the product. If this product really produced the results it claims it would become very popular and be sold in many places!

It does, read this :

http://www.molecularpain.com/content/7/1/3

http://www.google.com/url?sa=t&sourc...HLMFONVy2vekSA

http://www.ejog.org/article/S0301-21...042-4/abstract



Endometriosis is a chronic oestrogen-dependent gynaecological disorder, the most common symptom of which is pain. Inflammation can be considered one of the major causes of pain in endometriosis. In particular, degranulating mast cells have been found in significantly greater quantities in endometriotic lesions than in unaffected tissues. The increase in activated and degranulating mast cells is closely associated with nerve structures in painful endometriotic lesions. These observations indicate that inflammation due to mast cells may contribute to the development of pain and hyperalgesia in endometriosis. Controlling mast-cell activation may therefore relieve the pain associated with endometriotic lesions.


The preliminary results indicate that all patients enrolled experienced pain relief as early as 1 month after starting treatment. Furthermore, a reduction in the analgesic drugs usually employed for pain control was observed in all subjects treated. Additionally, some improvements in endometriotic lesions seemed to be demonstrated by imaging.


In neuropathy, mast cell often degranule pro inflammatory cell and growth factor like NGF.

Sometimes it is the cause of the disease :)

edited *******

When one reads studies or anecdotal things of a medical nature one has to keep in mind that most ideas written about never make it commercially or practically.

The publish or perish attitude in academia sometimes drives the papers. But also, luck seems to be working on many.

One of those you quoted in your first post involved ONE patient.
This just does not fly for very long.

Things that work...for PNs here, like lipoic acid have scads of papers over a decade on them, and still doctors are just learning about it. And it works, but few are using it, still.

http://www.google.com/url?sa=t&sourc...HLMFONVy2vekSA is the most important link.

Thanks for that PDF....

Those are very small gains with this product. I can get better pain relief with my magnets.!