Suspected usefull drugs
 

TOS is : inflammation, fibrosis, reperfusion ishemia and disfunction neuronal probably by de-differentiation process, and hypertropy.


Treating the fibrosis by reversing it :

Pentoxifylline 800mg tocopherol 1000mg / day for 3-24 months


Treating neurogenic inflammation to ease pain and fibrosis reversing :

Pentoxifylline 800mg and Cromoglicic acid (stabiliz mast cell) 600mg/day for 3-24 months


Treating reperfusion ishemia :

Pentoxifylline 800mg + tocopherol 1000mg + Cromoglicic acid (reduce calcium) for 3-24 months


Treating neuronal disfunction :

Pentoxifylline 800mg, progesterone or other agents eventually.


Treating hypertrophy wich is know to be reversible :

Theory 1 : inflammed nerve ending : Pentoxifylline and Cromoglicic acid
Theory 2 : Excitable nerve C fibers caused by inflammation loop : Cromoglicic acid
Theory 3 : Fibrosis of scalene make positional muscles in tension : Pentoxifylline + tocopherol


Pentoxifylline 800mg + tocopherol 1000mg + Cromoglicic acid for 3-24 months.


I am actually on Pentoxifylline 800mg + tocopherol since 1 months and 20 days.

Here my full explanations :

http://neurotalk.psychcentral.com/thread142171.html
http://neurotalk.psychcentral.com/thread143979.html

Seriously listen to me ....

TOS is sometimes named brachial plexus neuritis because of his autoimmune inflammation.

Here a study of PTX suppressing autoimmune neuritis :

http://www.ncbi.nlm.nih.gov/pubmed/8981293

"Peripheral neuropathy may be classified according to the number of nerves affected or the type of nerve cell affected (motor, sensory, autonomic), or the process affecting the nerves (e.g. inflammation in neuritis)."

Doctor ellis's proof are clear i think

PTX work for carpal tunnel here :

"In these patients 166 CTS were diagnosed of which 144 improved after the treatment, while the condition remained unchanged in 11 and even worsened in another 11 cases. Using the clinical and EMG criteria the findings were divided to mild, moderate and severe CTS. 77 mild CTS improved by 61% in average, 63 moderate CTS were improved by 47% and 26 of severe CTS improved by 50%."

http://www.ncbi.nlm.nih.gov/pubmed/10659375

Infos :

The vasa vasorum/vasa nervorum is probably the origin of TOS, along with ishemia reperfusion.

Acute ischemic lesions of the peripheral nerves can be
reversible but severe and prolonged ischemic process of
the nerves can lead to extensive axon injury along with
Wallerian degeneration (19). The severity of these lesions
depends on the duration and the intensity of ischaemia
and compression. Vasa nervorum can also be affected by
trauma, diabetes and by some metabolites. These factors
can lead to ischemic neuropathy (20,21,22) and
reperfusion injury during peripheral nerve injury (23).
Ischaemia leads an insufficient ATP supply when ATP
consumption in all damaged tissues increase. Anaerobic
metabolic process levels increase in such process and
eventually hypoxanthine levels also increase in ischemic
tissues. In the reperfusion phase of ischaemia superoxide
radical levels and hydrogen peroxide levels increase.
These can lead to the damage of the tissues (18 ).

Pentoxifylline had been used in some experimental
and clinical studies especially to restore the normal
function of the vasa vasorum.

:hug:

I wasn't sure what it was so I thought I'd post some of the info/sites I found.

Pentoxifylline info from drugs.com -
http://www.drugs.com/search.php?sear...Pentoxifylline
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000846

Traction or compression may result in ischemia, which initially damages the vasa vasorum. Severe compression injuries can result in intraneural hematomas, which can compress adjacent nerve tissue.

http://emedicine.medscape.com/article/316888-overview