Celiac Disease and Neuropathy
Hi,
Can anyone tell me how having Celiac Disease causes Neuropathy? Appreciate any information. BonDon |
BonDon
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This is a very readable explanation from Dr. Latov:
http://www.enabling.org/ia/celiac/do...%20article.pdf This is the link to the Gluten File online neuropathy section: https://sites.google.com/site/jccglu...eralneuropathy |
There are actually two different mecahnisms--
--by which celiac disease may cause neuropathy (and a host of other neuropathic conditions).
The first is the obvious one described here--villous atrophy leads to malabsorption of essential nutrients and deficiencies, which starves nerves (and other body tissues). But there is also mounting evidence that the gluten peptides, in those with susceptibility due to genetic background, can result in the production of antibodies that cross react with certain components of peripheral nerve. This autoimmune attack can damage the nerves, and it also may damage certain parts of the brain, especially the cerebellum--gluten ataxia, for example, is thought to result from this process mediated through damage to Purkinje cells. This can get biochemically complicated to explain--the Gluten File has a number of articles about it, of which this is relatively representative: http://brain.oxfordjournals.org/content/126/3/685.full Also, take a look at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077388/ https://sites.google.com/site/jccglu...eralneuropathy |
update on cd and pn
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Much of the current research into gluten sensitivity and celiac--
--since it is now established that this is a much more common entity than originally supposed, though still suffereing from some pooh-poohing about "trendiness" among many physicians, has been directed towards finding some more sensitive and accurate serological markers of celiac, such as looking for deamidated antibodies. There is also a lot of interest now in epidemiological surveys to explain what seems to be a rising incidence over the last half-century (many suspect genetic modification of gluten containing grains), and, of course, the pharmaceutical people are working on drugs to attempt to block the absorption or effect of gluten proteins in the intestine.
I still think The Gluten File is the best place to see ongoing articles, as it is updated frequently (although now JCC notes updates often wind up on Facebook first): https://sites.google.com/site/jccglutenfree/home Another thing one can do is set one's e-mail program to cull news alerts with such words as "celiac" and "gluten" in them. While this does bring in a lot of celebrity stuff, it also pulls in reports of studies and one can then follow these to their sources. For instance, here's a conference in Chicago at which I'm sure a lot will be shared: http://www.news-medical.net/news/201...ICDS-2013.aspx Or, one can always search through PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=celiac |
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