Serum metal levels
 

Ahmed and Santosh [1] measured the serum levels of various metals in PD (n=45) and non-PD (n=42) people in South India.

They found that "Al [high in PwP], Cu [high], Fe [low], Mn [high] and Zn [low] were dominantly reponsible for the separation of PD from normal".

They went on to look at the correlation between metal ratios and PD: "Al/Cu, Al/Fe, Al/Mn, Al/Zn, Cu/Fe, Cu/Zn, Fe/Zn and Mn/Zn were increased and Fe/Mn and Cu/Mn were decreased in PD compared to healthy control".

They describe a neural network (a computing technique, ironically inspired by the working of the brain) which, taking together all the relationships, gives a 95% diagnostic accuracy. (But, note the small sample size.)

Reference

[1] Ahmed SSSJ, Santosh W (2010) Metallomic Profiling and Linkage Map Analysis of Early Parkinson's Disease: A New Insight to Aluminum Marker for the Possible Diagnosis. PLoS ONE 5(6): e11252. doi:10.1371/journal.pone.0011252
http://www.plosone.org/article/info%...l.pone.0011252

John

High aluminum level
 

Hi John, in 2008 I found out very high aluminum levels (+200 out of 20). After doing about 20 sessions of chelation therapy (EDTA), my parameters were normalized, but my symptoms went on slowly and progressively the same. There must surely be a connection between high heavy metal levels in blood and PD, particularly in Manganese (see links about Mn and mitochondria health, in previous posts).

Revisiting Mark Purdey...he thinks manganese too
 

I think this supports Mark Purdey's theory that neurodegenerative disease is due to metal disturbance that results in protein turned assault prion in the brain. He takes it further noting how it all relies on magnetic field input from environment. He is also one of the first to notice the disruption in our Circadian rhythms.

At first I thought, pish posh on the magnetic field stuff but therapies using TicoPesla magnetic resonators seem to help and are in clinical trial phase III. There is an energy component to the disease origin too. Here in Purdey's own words:

Although discarded by Establishment bodies, the phenomena of the disease cluster provides an ideal research tool for identifying the true environmental causes of a given illness; which, in turn, paves the way for identifying the best means of eradicating, preventing, and even curing that disease. But, sadly, the unilateral research direction of the multinational-ministerial grand alliance is purely designed to develop the most effective means of suppressing symptoms of disease through formulation of pharmaceuticals, gene manipulation, etc; Such an approach fails to deal with the root cause.

My work focuses on the biological impact of the increasing cocktail of environmental oxidizing agents in our modern environment; eg, ultra violet radiation, systemic insecticides, low frequency infrasonic radiation, radar, microwaves, etc. I am studying the oxidative impact that these agents exert upon various transition metals in the brain - manganese, silver, etc - and how they are transformed into pathogenic 3+ or 4+ species which carries a lethal oxidative capacity that is capable of initiating a self perpetuating free radical mediated neuro degeneration.

To the source in general www.markpurdey.com

I have attached maps of his epidemiological study on vJD (Variant of Jakob Cruetzfeld Disease).

Following on from my previous post, let's see how this fits in with the spatial epidemiology of PD.

As we've done before, we start with the paper by Willis et al. [1] which shows geographical variations in the incidence [2] of PD across the US. Roughly speaking, the west has low incidence and the east (from Texas north-eastwards) has high incidence.

If aluminium plays a part in the aetiology of PD, its spatial distribution, as far as ingestion is concerned, should match that of PD.

Where does the aluminium come from:
- pots, pans, cans;
- water;
- food
- pollution.

The aluminium content of food and water will, to the extent that it is sourced locally, in part, depend on the amount of aluminium in the soil. The distribution of this across the US is given by Shacklette and Boerngen [3]. It shows almost the opposite distribution to that of PD:
Average aluminium content either side of 96th meridian
West 5.8%
East 3.3%

However, what probably really matters is the rate at which the aluminium leaches from the soil. This will depend, in part, on the pH of the rainfall [4] which is high to the west (an "eye-balled" average of 5.5) and low to the east (4.6).

It turns out that this difference has a completely disproportionate effect on solubility [5]: going from a pH of 5.5 to a pH of 4.6 the solubility quadrouples. This more than makes up for the original lower level of aluminium.

This acidity has a double whammy: it leads to greater leaching from pots, pans and cans.

No claim is made that aluminium is the cause of PD. Rather, we have shown that a role for aluminium in the aetiology of Parkinson's is not blown out of the water by the epidemiological evidence.

References

[1] "Geographic and Ethnic Variation in Parkinson Disease: A Population-Based Study of US Medicare Beneficiaries"
Willis A., Evanoff B., Lian M., Criswell S., Racette B.
Neuroepidemiology. 2010 April; 34(3): 143–151.
Published online 2010 January 15. doi: 10.1159/000275491
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865395/

[2] http://www.ncbi.nlm.nih.gov/pmc/arti...395/figure/F2/

[3] "Element Concentrations in Soils and Other Surfici 1Materials of the Conterminous United"
U.S. Geological Survey professional paper 1270
Shacklette H., Boerngen J.
http://pubs.usgs.gov/pp/1270/pdf/PP1270_508.pdf

[4] "Acid Rain and Acid Deposition"
http://oceanworld.tamu.edu/resources.../acidrain.html

[5] "Soil Aluminium and Soil Test Interpretation" http://www.spectrumanalytic.com/supp...rpretation.htm

John

by the way...
 

By the way, few years ago, I started chelation therapy, after reading the story of Matteo Dall'Osso, a young boy with MS. He wrote in his blog, an amazing story (his true real life) which describes his struggle against MS and a sort of narrow-mindedness of some neurologists. This is the link of his blog (completely for free) to read or download his story.
Currently he feels much better, and had many improvements, thanks to some supplements such as: Glutathione, B12 Vitamin and other... in addition to chelation therapy.

http://www.matteodallosso.org/eng/

http://www.matteodallosso.org/eng/?page_id=6

I tried the same route, but I didn't reach great improvements. (I think).

John,

In addition to cookware, aluminum is an active ingredient in antiperspirants.


Not sure if this makes a difference in your current stats or not.

Laura

Brain aluminium half-life
 

Sim00,

Thanks for your posts.

You mention that you underwent chelaton, but you observed no improvement of symptoms or even a slowing of progression. This is an important observation.

I'll be grateful if you'd clarify a few things:
- You started with very high aluminium levels. What was measured?
- You scored +200 out of 20. Does this mean that your levels were 220 of some unit, while the average was 20?
- After 20 sessions your levels were normalized. What was measured?
- How long was there from the first to the last chelation session?

There is some literature suggesting that, in respect to aluminium, at least, the blood brain barrier is asymmetric, being easier to get in than out. Once in the brain the aluminium becomes semipermanent [1].

Yokel et al. [2] write that the amount of aluminium in the brains of rats decreases "with a half-life of approximately 150 days" without chelation and approximately 55 days with. Estimates of the half-life of aluminium in human brains vary: 7 years is one [3].

These effects could lead to normal readings outside the brain, while inside the brain aluminium levels would still be high enough to continue doing damage.

References

[1] "Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses"
Masahiro Kawahara1 and Midori Kato-Negishi2
International Journal of Alzheimer's DiseaseVolume 2011 (2011), Article ID 276393, 17 pagesdoi:10.4061/2011/276393
http://www.hindawi.com/journals/ijad/2011/276393/

[2] "Entry, half-life, and desferrioxamine-accelerated clearance of brain aluminum after a single (26)Al exposure."
Yokel RA, Rhineheimer SS, Sharma P, Elmore D, McNamara PJ.
Thttp://www.ncbi.nlm.nih.gov/pubmed/11606803oxicol Sci. 2001 Nov;64(1):77-82.

[3] "Aluminium toxicity"
http://www.medicalassessmentonline.net/terms.php?R=529

John

Acidic drinks
 

Laura,

Thanks for your posts.

The use of aluminium in antiperspirants must add more to the body.

I'd add that the move away from drinking water to drinking fruit juice and fizzy drinks is also likely to have led to an increase in the absorption of aluminium [1].

I'd guess the move to acidic drinks accelerated in the US in the 1950s and in the UK in the 1970s. If the theory holds water, it should have led to higher PD age related incidence rates. Anyone got any data?

Reference

[1] "Orange juice enhances aluminium absorption from antacid preparation."
Fairweather-Tait S, Hickson K., McGraw B, Reid M.
Eur J Clin Nutr, 1994 Jan; 48(1): 71-3
http://www.ncbi.nlm.nih.gov/pubmed/8200332

John

Hello John,
I will try to be more accurate. Regarding chelation therapy which I made, it's IV (EDTA + C vitamin + other electrolytes) performed with slow infusion (about 2 hours) according with ACAM protocol (American college for advancement in medicine).

http://www.acamnet.org/site/c.ltJWJ4..._Chelation.htm

Final score were measured in a specialistic lab, taking urine sample, after each chelation session.

Maximum level of aluminum in the measurement scale was: 20 micrograms / liter. My values ​​to the first infusion were 169, at the fourth were 207, at the eighth were 134, at the twelfth were 206, at the fifteenth were 123, at the eighteenth were 60. I also measured mercury and lead, but they were always in the range.

Total number of sessions was performed in about 18 months.

I also removed all my old teeth fillings in my mouth.

My next step will be to investigate about Manganese level in my body.
Do you remember some posts ago, what I linked?

http://neurotalk.psychcentral.com/thread166072.html

Look carefully the three videos that I linked. :eek::eek::eek:

Sim00,

Thanks for answering my questions so quickly.

If I understand you correctly, the level of aluminium in your brain was never measured. Also, if the long half-life values are correct, there may have been insufficient time for the process to have had a noticeable effect.

So I think the theory is still afloat.

Does liposomal chelation work?

John