Nicotine patch ... Anything new?
 

Has anyone hear qgain from Villers from France?

Hello


I just wrote about my big progress through the Nicotine patches protocol in Dr Paneri thread .
My progress are remarkable .
it worked for me,and i will just continue this Nicotine protocol for the years to come.

kind regards

Are you still doing Dr. Paneri's therapy.? Can I use just any nicotine patch or does it have to be a specific brand , with specific ingredients.

Patch article
 

The posts on nicotine have caught my interest. It seems that all promising future treatments for PD remain in the future, we have to find ways to self treat. Nicotine patch's or gum can be bought online and since it is a well known "drug" there is not a lot of risk to experiment. Below is a report, from France?, on what's new with the patch.


http://www.medscape.com/viewarticle/746713_1


Five-year View

On the basis of clinical observation of single cases treated by transdermal nicotine, it appears that clinical response may vary to a major extent between individuals. This variability may be explained by different phenotypes in the clinical spectrum of PD. As growing evidence support the genetic susceptibility of most patients to PD, genetic differences on the disease itself or the pharmacological response of individuals to drugs can explain these major differences of clinical response between individuals.
The therapeutic role of nicotine may result from metabolic or receptor-mediated effects (vide supra). It is therefore probable that other nicotinic agonists, acting on one single receptor category or with one mechanism of action, will cross the gap between experimental research and clinical trials. One example is the recent study of two targeted nicotinic acetylcholine receptors agonists varenicline and A85380, which resulted in a significant decline in levodopa-induced abnormal involuntary movements at a relatively low dose of the agonist, with no worsening of Parkinsonism.[57] Finally, other tobacco smoke compounds may account, at least in part, for the neuroprotective effect.[58]

Disease modifying potential of nicotine
 

Does anyone have any first-hand experience with whether nicotine patches have slowed down the progress of PD?

Thinking about signing up for the nicotine trial. I'm 6 months in the diagnosis 46 yo. Probably about 2-3 years of symptoms though. My dad diagnosed about 10 years ago. He is still hanging in there, but the last couple years he really progressed. Two older uncles that have both passed away from PD and other stuff. My one uncle that died a couple years ago was the oldest and a heavy smoker his entire life basically.

He seemed to really go downhill fast when they made him quit at the nursing home facility. He was about 12 years older than my dad. He used to basically live on coffee and cigarettes, but did not show the symptoms of PD. He had pretty bad dementia before we decided to put him a nursing facility. It was a bad situation getting him away from the woman he married and was using him for money. That messed him up pretty bad. When they restricted the coffee and cigs he had the exact symptoms my other uncle that died and dad has now.

Anyway after seeing him shortly after quitting smoking, and not being able to drink coffee all day it made me think that he was getting some benefit back when he could. Worth investigating on my part.

Villiers, Anything new?
 

Hope you have continue in your good progress. Is there any new or positive in you can share with us?

Calling Villiers, Love to know how you are doing and if anything new. I'm doing great going on 6 or 7 months.

Hello Hello
 

I am still on my Nicotine patches and going well .
At the present times,i am on a 29 mg dose (1 patch of 21mg + 7 mg ).
I used to be on 42 mg until August... but in August,i did a Big,big Mistake...i was feeling so well that i stopped patching for Almost 3 weeks ( i was by the sea,so patching with all those sea bathing seemed not appropriate...when i came back to Paris,All my PD symptoms were back like 3 years ago !!...terrible moment....so the Nicotine does really ,really make a huge positive difference...i am certain now...i learned it the rough way ! ...so my Neuro told me to start back at 21 meg...and 29 mg ,after 1 month

At this present time,i only need to take my first Sinemet at 1 pm/2 pm...as when i wake up around 8.30 am,i am in excellent shape ,no need for levadopa...

I stopped taking Azilect since May...as it was making me super depressed ...especially in the Evening hours...since i stopped Azilect,those dark thoughts have vanished

And since 1 week ,i am doing the Terry wahls diet ,eating a lot more of raw food,and drinking fresh homemade green and fruit juices ...i am taking 1 g of organic curcuma powder with a bit of black pepper too...

My big problems since a few months was the Freezing that Sinemet was giving me ( i was freezing for 45mn- 1 hour every time i was taking a sine met..) My freezing is almost gone now since i dissolve the sine met in a glass with water then drink it...