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-   -   Safety of pentoxifylline 800 + tocopherol 1000ui (https://www.neurotalk.org/thoracic-outlet-syndrome/160813-safety-pentoxifylline-800-tocopherol-1000ui.html)

boytos 11-15-2011 05:37 PM

Safety of pentoxifylline 800 + tocopherol 1000ui
 
There were some reservations for the possible increased risks of tumor with systemic very long-term use of pentoxifylline 800 / tocopherol 1000 (to possibly reduce the fibrosis, or at least making it way more soft in scalenes) but it turns out finally that the risks are extremely low, if any. There are no suspected cases and the duration for us would be more like 2-3 years than 8 years. Yes i know, it is a weak treatment but it seem to work with time and patience.

http://www.slideshare.net/tmm50/pentoclo
http://www.ncbi.nlm.nih.gov/pubmed/20638190
http://www.ncbi.nlm.nih.gov/pubmed/15641107
http://www.sciencedirect.com/science...60301698004192

In the studies tgf-b1 was totally abolished with the use of ciprofloxacin without more side effects.

http://www.asco.org/ascov2/Meetings/...bstractID=9827

an the list goes on and on.

Rats and mouse experiences show just a little increase in bening tumor with 19 times the maximal human dose (1200 a day x19) for 18 months.
http://products.sanofi.us/trental/trental.pdf

And recent studies sugest that large amounth of tocopherol slighly increase risk of cancer prostate if taken without selenium or gamma tocopherol. We can fix it.

In addition others tgf-b1 inhibitor, know as ACEi actually decreases risks of cancer.

In conclusion it seems very safe, even in cancer patients, but given the fact that anti tgf-b1 therapy may be possible localy, it may be better to wait and see.

Maybe we can reduce scalene's fibrosis and make them more soft, in the safest way as possible. :)

nukenurse 11-19-2011 07:52 PM

I've been taking pentoxifylline (sp?) and ARBs (angiotensin receptor blockers) for the last 2 years for my TOS w/ good results. Recently added EPO + DMSO for even better results. Have a feeling that botox + cortisone shot to the scalene would be sublime. Working on acquiring fasudil --- looks promising.

boytos 11-20-2011 06:12 AM

seriously ? 1000 toco ui may be much better than acei for their synergetic action.

if you like to try drugs like this, i recommend a safer one : normast.


Who give you these drugs ?

nukenurse 11-20-2011 10:42 AM

i've seen normast ---- it has PEA which is effective w/ peripheral nerve injuries. I might try it some time. If you try it let me know how it works for you.

boytos 11-20-2011 11:17 AM

who give you these drugs :confused:

how much pentoxifylline/ARBs ?

nukenurse 11-22-2011 01:26 AM

boytos,

if you want more info, please send me a private message with your email address and i will send it to you there.

Thanks,
trojan

nukenurse 11-30-2011 04:28 PM

scratch the idea about cortisone ---- I was told it doesn't help.


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