NeuroTalk Support Groups - Inhibiting the Neurotransmitter Acetylcholine In Parkinson's Disease

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Inhibiting the Neurotransmitter Acetylcholine In Parkinson's Disease

I stumbled on the following article which suggests alternative natural route to PD treatment which makes sense to me. What do you think ?
Imad

http://www.restoreunity.org/inhibiti..._parkinson.htm

Quote:

The symptoms of Parkinson's Disease, such as tremors, rigidity, postural instability, and other disorders of movement, are considered a result of declining levels of the neurotransmitter dopamine. In Parkinson's Disease there is a degenerative process in the brain that leads to a marked decrease in synthesis of dopamine and a resultant drop in its levels in the substantia nigra and corpus striatum (two areas of the brain where dopamine synthesis is important). The lowering of dopamine results in raising the ratio of acetylcholine to dopamine, in cells of the nigrostriatal system. Acetylcholine is the neurotransmitter that stimulates muscle cells. It is considered that the higher ratio of acetylcholine to dopamine leads to over-stimulating muscle cells and this imbalance contributes to the various disorders of movement found in Parkinson's Disease.

Quote:

In conclusion, Parkinson's is a disease of accelerated aging. Motor symptoms, brain degeneration, decrease in cognitive function, and other problems of Parkinson's lead to decline in efficiency and function of the brain and body, which results in further degeneration, aging, and breakdown. This is a downward spiral of declining efficiency and function. Each symptom and problem of Parkinson's needs to be neutralized, in order to slow down the aging process. There is no magic bullet cure. Each specific condition must be dealt with and methods of anti-aging can be used. The ideas in this article are to help in one aspect of Parkinson's, to help inhibit the activation of acetylcholine and the overstimulation of epinephrine. Good luck.

to read the full article please go to
http://www.restoreunity.org/inhibiti..._parkinson.htm

reminder...additional resources

You can always check out our online research forum www.pdonlineresearch.org

Here is what you get when you search 'acetylcholine' on PDOR... http://www.pdonlineresearch.org/sear.../Acetylcholine

Additionally, you can go to www.michaeljfox.org and search the term to see if/how MJFF as been involved. The link below shows the results from a search of 'acetylcholine' on our corporate web site.

http://www.michaeljfox.org/search.cf...hOption=entire

Debi

PS...admittedly, these search functions don't always deliver the best results within our site (ie, more maybe be within our site than show up on a given search term) so clever searching will yield better results -- we are working to upgrade our "search" function.

I know your post was about natural remedies but I have read oral GABA does not cross the BBB in sufficient quantity to make any difference. However, Neurologix is working on GABA gene therapy, I believe they concluded phase II of their trial and many are waiting on those results. Phase I was apparently a success. MJFF may also be involved with Neurologix.

Paula has posted quite a bit here about messing with acetylcholine levels, you may want to review those posts.

Thanks for sharing this, very interesting. 108 is incredible to me.

Increasing the Efficiency of Dopamine in Parkinson's Disease

I found following article from same website interesting and again offers suggestions of alternative 'natural' PD treatment. I hope to see your comments.

http://www.restoreunity.org/increase_eff_dopamine.htm

Quote:

to read the full article please go to
http://www.restoreunity.org/increase_eff_dopamine.htm

"To decrease the amount of dopamine needed as a precursor for epinephrine and norepinephrine, thereby helping to preserve dopamine, you can increase the efficiency of epinephrine. This will result in less depletion of dopamine."

Hi Imad,

I couldn't agree more with this doctor. We run out of norepinephrine like we run out of dopamine, which, in turn causes an imbalance of acetylcholine [initiates muscle movement - goes berserk thus tremor, bradykinesia, etc.] and GABA, the regulator of adrenalin and over firing.

i made a mistake in my interpretation. Seems reuptake has been studied and nortriptyline does lower acetycholine but it inhibits the reuptake of norepinephrine, which helps to balance the norepinephrine and seratonin. My bad sorry!