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-   -   Interferon Alfa-n3 (https://www.neurotalk.org/multiple-sclerosis/105243-interferon-alfa-n3.html)

EddieF 10-10-2009 11:08 AM

Interferon Alfa-n3
 
This drug got a friend of mine out of wheelchair after taking it 1 1/2 yrs.

He had MS for years, progressed to wheelchair, then hospital bed.
Dr. told him "take this" and you'll be out of chair in 1 1/2 yrs. It worked.
It dissapeared approx 4 yrs ago. Was originally released for Genatle Herpes Warts.
Off label uses are chronic hepatitis c, hairy cell leukemia, malignant melanoma, aids-related Kaposi's disease, bladder cancer, carcinoid syndrome, renal cancer, multiple myeloma, ovarian cancer, ect.
Amazing drug that i've also called fda and co on. We both got different answers why it's not available. It's still able to be prescribed.
Still in pharmacy's system if you call for price check. Alferon N by Hemispherx. Both our conclusions are it was too good for the money.

Remember that name Interferon Alfa-n3.

Thankyou

SallyC 10-10-2009 01:58 PM

Here is an informative link....


http://www.medscape.com/viewarticle/408383_5

EddieF 10-11-2009 07:53 PM

Thankyou and if it's ok to quote the article which I believe should:

Patients receiving IFN alfa-n3 were significantly younger and had a longer disease duration than the other patients.
The MRI lesion loads and EDSS scores were significantly reduced at 1 year in the IFN alfa-n3 vs the untreated group.
Median lesion volume change was -7.2% for IFN beta-1b vs +11.7% for untreated patients and -10.4% for patients receiving IFN alfa-n3 (P = .009).
Mean EDSS change at 1 year was -0.20 in IFN beta-1b, +0.68 for untreated, and -1.13 for IFN alfa-n3 patients (IFN beta-1b vs untreated, P = .02; IFN alfa-n3 vs untreated, P = .0001).
No significant adverse effects were seen in the IFN alfa-n3 group, except for 1 case of deep venous thrombosis. These data should be interpreted with caution, since the study was open-label, retrospective, nonrandomized, and the clinical evaluations were unblinded.
However, further study of the efficacy of IFN alfa-n3 in MS is warranted. Dr. Sheremata, the senior author of the study, commented that "follow-up studies are planned" at his comprehensive MS center at the University of Miami.

Funny thing..my friend was in a Miami hospital..13? years ago.
I didn't see a article date. It performed a miracle on him. I'd like the same.

kicker 10-12-2009 08:16 AM

I believe it helped your friend, the article is positive but I've never heard of this. Anyone? Any trials ever done? Any European info?

kicker 10-12-2009 08:30 AM

Did a little research - seems most recent I could find was '04 info. I'm not very good at understanding info, there are others good at this but IMHO Interferon A is a more tolerated form of Interferon than B which some can not take? Anyone really know? Sounds RR, me being PP I know it would never help me.

EddieF 10-16-2009 07:54 PM

http://www.biospace.com/news_story.a...ityId=15487620

Article states all worldwide rights were bought by co. March 2004. They mightve sold off the remaining stock acquired from last co. and then quit.
Doesnt make sense to buy rights and not produce. Fishy.

EddieF 03-29-2010 07:29 PM

Update - They're now testing an oral form (Alferon LDO) currently in Phase 2 trials for HIV.
My guess is Alferon was so successful at things they never dreamed of, that they pulled it to rerelease at higher cost.
Below is/was approved off label uses. I asked a hema/oncologist if he knew of any ONE drug for all listed. He said no. This is alfa, this one beta, these alfa, this one gamma. He told me their nasty drugs too for side effects. The person I know that took it hasnt returned my calls in months. I never got side effect info from him.

chronic hepatitis c
hairy cell leukemia
malignant melanoma
aids-related Kaposi's disease
bladder cancer
carcinoid syndrome
renal cancer
multiple myeloma
ovarian cancer

The co. told me it was one issue, I called fda they said no issues on our end.
Had fda call them and they got different answer.
I called again months later and they told me dea issue.
I havent given up yet. Emailed the lady running trails but no reply. Will call.
Its scarry that a genitle herepes warts drug worked and now its being tried for HIV but this leads me to wonder if an existing HIV or herpes drug would have similar effect.

Lady 04-01-2010 11:47 PM

Eddie, They use LDN for HIV and many cancers too. Also to prevent cancer.

Pink 04-02-2010 01:53 AM

To put it simply - I see much more promise in LDN. It has proven itself (IMO) as a very good possible alternative to traditional MS treatments as well as several chronic.... I suffer from MS & another (not HIV) and as such have research on LDN. While still not sure of what to do in my position, I do not see LNO as the best. It needs much more research, trials....

EddieF 04-02-2010 07:32 PM

After looking up what LDN is all I can say is wow! and why the heck hasnt my neuro mentioned this since Ty after 5 infusions isnt performing miracles on me? Looks like there IS a connection between these hiv drugs and helping MS. Thankyou! Not sure about blocking recepters mentioned but if it works..
And the fact they said it boosts imune system, I dont see a conflict with Ty. Anyone?


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