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-   -   What? Scientists remove beta-amyloid plaques from live animal brain (https://www.neurotalk.org/parkinson-s-disease/105892-scientists-remove-beta-amyloid-plaques-live-animal-brain.html)

lurkingforacure 10-17-2009 08:34 PM

What? Scientists remove beta-amyloid plaques from live animal brain
 
Here's the link...if I am reading this right, the activated microglia made things better? This doesn't reconcile with most of what I have read to date, that the activated microglia cause problems...http://www.sciencedaily.com/releases...1015091602.htm

reverett123 10-18-2009 05:39 AM

Quote:

Originally Posted by lurkingforacure (Post 579314)
Here's the link...if I am reading this right, the activated microglia made things better? This doesn't reconcile with most of what I have read to date, that the activated microglia cause problems...http://www.sciencedaily.com/releases...1015091602.htm

The difference is in the two diseases, I think. The problem with microglia in PD is that they don't turn off. In the study they were intentionally turned on and attacked the plaque. I use the analogy of teenage boys with nothing to do vs the same boys with a purpose:

"This is in contract to PD where the same cells when chronically activated have no plaques to target. Like a bunch of teenage rowdies unemployed and hanging out on the street corner, they degrade the whole neighborhood due to a lack of focus. Rumors of threats from surrounding neighborhoods keep tensions high even though they don’t materialize. Give them the needed focus, cleaning the junk off the local basketball court for example, and they improve things they would otherwise have degraded." More...


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