B 12 results, Huge improvement. too much?
 

Just received (via mail) my new B12 results. Went from 300 to 1880 in about 6-8 months. Took 5 mg sublingual methyl daily (semi faithfully).
Gosh - now I hope it isn't too high. don't see the dr. for anther month. Considering taking it less frequently.
Is 1880 too high?
Sydney

No, it is not too high
 

Glenn's answer to your same question asked on a different thread is right on. It is safe and positive to have a very strong B12 level.

rose

Hi beglobal,

I can offer a few articles about B12 deficiency, and what sort of symptoms may accompany it~ The symptoms can be wide ranging and include neurological, neuromuscular, cognitive and other problems.

B12 isn't any sort of cure all, but in those who have underlying B12 deficiency, it can literally be life saving. B12 deficiency is often missed because doctors don't think to test for it, and because lab ranges are set too low.

Hope this helps!

Cara




eMedicine link on vitamin B12 associated neurological diseases:

AAFP on Vitamin B12 Deficiency

Subacute combined degeneration: clinical, electrophysiological, and magnetic resonance imaging findings JNNP

Emedicine on Pernicious Anemia

PDRHealth on Vitamin B12

Life Extensions magazine article on B12

And here is a list of symptoms that Rose has frequently posted for us, but no list is complete:

Quote:

Goldman: Cecil medical textbook --- Saunders 2000 page 865 TABLE 163-4 -- NEUROPSYCHIATRIC ABNORMALITIES * THAT MAY BE CAUSED BY COBALAMIN DEFICIENCY Paresthesia Depression Impaired vibration sense Paranoia Impaired position sense Listlessness Impaired touch or pain perception Acute confusional state Ataxia Hallucinations Abnormal gait Delusions Fatigue Insomnia Memory loss Apprehensiveness Disorientation Psychosis Obtundation Slow mentation Decreased reflexes Paraphrenia Weakness Mania Decreased muscle strength Panic attacks Romberg's sign Personality change Increased reflexes Suicide Spasticity Babinski's sign Lhermitte's sign Urinary or fecal incontinence Urinary urgency or nocturia Impotence Abnormal smell or taste Decreased vision or optic atrophy "*These abnormalities may be present in any number or combination in a given patient. They are seen frequently with or without any of the hematologic or other abnormalities listed in Table 163-3."

Hello BeGlobal...
 

B12...well you basically cannot live without it.

You could say it is a "global" vitamin.;)

While it is not on the list provided by jcc, B12 has recently been found
to be necessary to prevent bone loss.
http://www.sciencedaily.com/releases...0421235233.htm

I am wondering as well, what those links are in your signature?
I typically don't click on hyperlinks, so I am interested. Do you use those products? Is that why they are there?

Hi Rose- I just want to double check with you as I know you are expert on this. I had very low B12 and neurosymptoms (dizzyness, parasthesias, decreased left hand function very min cognitive change) dxd in fall 2004. I had frequent B12 injections until recovery (no more dizzyness, very mild parasthesias). Then we went to 1,000 micrograms via shot 1x per month. Last fall I had a very slight increase in symptoms and my doc upped this to 1,00 micrograms 2x per month. The doc is worried this may be "too much" and I am worried that if we reduce it my myelination may decrease/symptoms may return. Do you know if there is any research about the effects of a high dose of B12 given over time and long term impact?

Ill look forward to your advice. I hope you are well.

Sincerely, Rachel Hitch

Hi Rachel,

Until Rose gets here.... here are some references I have in regard to B12 treatment. Most of the information I have has come through Rose :).

You might want to talk to your doctor about trying oral supplementation (1000-2000mcg DAILY). Some people have reported that they have symptoms or slumps between the shots whereas the daily oral supplementation actually worked better for them...a more steady supply of B12. I would worry about whether you are getting enough B12. I would not worry about too much. Rose may have more to add when she sees this.


On dosage, from:
Vitamin B12 Deficiency
ROBERT C. OH, CPT, MC, USA, U.S. Army Health Clinic, Darmstadt, Germany
DAVID L. BROWN, MAJ, MC, USA,Madigan Army Medical Center, Fort Lewis,Washington

"Contrary to prevailing medical practice, studies show that supplementation with oral vitamin B12 is a safe and effective treatment for the B12 deficiency state. Even when intrinsic factor is not present to aid in the absorption of vitamin B12 (pernicious anemia) or in other diseases that affect the usual absorption sites in the terminal ileum, oral therapy remains effective.

"Although the daily requirement of vitamin B12 is approximately 2 mcg, the initial oral replacement dosage consists of a single daily dose of 1,000 to 2,000 mcg (Table 4). This high dose is required because of the variable absorption of oral vitamin B12 in doses of 500 mcg or less.19 This regimen has been shown to be safe, cost effective, and well tolerated by patients."


Regarding oral B12:
Goldman: Cecil medical textbook --- Saunders 2000
COBALAMIN DEFICIENCY.
"One option is intramuscular or subcutaneous administration of cyanocobalamin. . . . Oral cobalamin therapy in a dose of 1000 to 2000 mug/day has recently been shown to be as effective and possibly superior to the standard parenteral regimen. Both regimens give prompt and equivalent hematologic and neurologic responses, but post-treatment serum cobalamin levels are significantly higher and post-treatment methylmalonic acid levels are significantly lower with the oral regimen. Oral cobalamin, 1000 to 2000 mug [mcg]/day, is the treatment of choice for most patients."

Is Oral Vitamin B12 as Effective as Intramuscular Injection?
http://www.aafp.org/afp/20060101/cochrane.html#c2

On Oral Dosing
Comparing costs of intramuscular and oral vitamin B12 administration in primary care: A cost-minimization analysis. 2006

Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: a systematic review of randomized controlled trials. PMID: 16585128 June 2006

Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. PMID: 15911731 May 2005


Hope this helps!

Cara

Rachel,

Cara's information is very good. She has taken what I did and run with it way beyond the goal posts. :)

There has been sooooo much research for so many decades that even a particularly good mainstream textbook has had no qualms for many years about saying B12 is safe in very large repetitive doses. And the B12 the textbook refers to is the cheapest in lowest in quality. If any were to cause a problem it would be the cyanocobalamin type.

In fact, in recent decades much research has shown that huge (daily injections, even in a person who cannot discard B12 with the urine) doses of methylcobalamin are safe.

If I were you, I would prefer to take at least 1000 mcg methylcobalamin, either in addition to or instead of the shots.

rose

b12 levels
 

Hi Everyone!

Hope all are well.

I just came from Neuro visit on Friday, I've been receiving b12 shots weekly since May. 1000mcgs.

Doc is shocked that all year my levels remained at 700, then increased this month to 821.........says by all accounts it should be in the "tens of thousands".

Still having nasty attacks/flares and being tested for a wealth of other vitamins to see what else I could be lacking.

Do you think he's right in saying my b12 levels should be sky high?

thanks,
lah

Finaly some else who has Subacute Combined Degeneration, I no longer feel all alone.
Mines is the worst my MD has ever seen, tell me do you suffer from short term paralysis of your arms and legs, or am I the only one?

hey fellow SCD'er!!!!!!!
 

Hi Dorvad,
How are you doing?

Short term paralysis? Sorry, no I can not say that I have that...........but it seems that I have EVERYTHING else that you can imagine.

How long for you to get dx'd from first symptom?
How low was your b12 levels?
How much b12 do you take?
What form?
Do you have any other health issues that may be involved?

My neuro thinks that the Medullary Sponge Kidney Disease that I have may have something to do with this.

Retesting me for some sort of mitochondrial thingie.

What are your symptoms?
Do they come and go regularly?
Do they sneak up on you in an "attack" or "flare up"
tell me tell me!!!!

thanks
lah

ps: with regard to the levels,
I read on the back of my GNS Gold Standard vitamins that my DH gave me for Christmas,
(and that may or may not -doc thinks not-have boosted my 700 level to 821--but did not prevent another nasty attack)
-any way on the back of the bottle it says
150 mcgs = 2500% of the RDA
so
no wonder he was flabberghasted at the 1000mcgs weekly for 8 months leaving me still with such low levels........
he just couldn't stop saying over and over "1000 mcgs!!!"
we even stopped at his collegues desk to chat about it on the way to the nurses station with my chart.
He tells the other doc and that guy says, "Gee, there's a real problem there"
no kiddin' :)