I need some help for my sister
 

Thank you in advance. My sister has had Fibromylgia for many years and takes Lyrica among many other medicine. She also has orthopedic problems and she takes Ultram for that pain. My question is does the Lyrica take care of pain other than fibromaylgia. I can't really say I understand the medicine. She had a knee replacement several years ago and about 2 months they had to take it out. She was put on Percocet after surgery. So she was taking all three medicine. She is falling a lot and as a nurse my first thought is medicine related. She has fallen every day this week She has an OT coming out to her home tomorrow to assess her home and see how they can help her safely do her ADL. Again, thank you.

I would say the Percocet... maybe dose related.

Lyrica is sedating, and so is Ultram, and when you add the potent Percocet, it might be too much. After two months she should not need the Percocet so much anyway.
While needing the major pain relief, she might have been able to drop the Ultram, (taper off) while using the Percocet.
They both work on mu receptors, but Percocet is much stronger.

Ultram and Lyrica should be tapered off if discontinued or reduced.

I'd also get the thyroid checked. Some older patients, get temporarily hypo when they have trauma or surgery. Low thyroid would make her weaker etc.

These are just some ideas.