Research brings cure for Parkinson's disease a step closer
|
This is huge!
Quote:
This is one to watch. Laura |
Bump
Bump.
If you wonder where freezing and slow movement come from and why it is only our habitual, automatic movements that are impacted, read the article Soccertese posted. It seems to make a lot of sense to me and hopefully this will lead to improved treatments in the future or targeted neuroprotection. |
Engineering model
Laura,
“Numerous experiments show that the loss of dopamine from the basal ganglia increases inhibitory output from the habitual control circuits” I happen to be a control engineer and the article sighted makes some sense to me. Any man made dynamic system (for example the control system driving a rocket) must include a feed forward signal defining the immediate goal for movement (intention) AND a feed back signal quantifying the actual movement achieved. In engineering terms the feed back signal is used to attenuate and correct the feed forward signal (i.e. inhibitory and it is typically called a negative feed back signal). Of course this happens in a continuous manner in infinitesimal small steps. The science of man made control systems essentially aims at smooth movement by manipulating the feed back signal. For example, too much negative feed back signal will make movement sluggish. Too little (negative feedback) may result in uncontrolled or oscillatory movement. This is a simplified picture and hope it helps. Imad |
Imad, I remember reading an article in which the cause of tremor was described exactly in the same terms as as your engineering model, interestingly rigidity was also postulated in the same way - as a fine extreme of oscillation, and linked to the sensation of 'internal tremor' that many pwp with no apparent tremor feel...... for those of us who had no way to describe this prior to dx it was often put down to panic attacks, which I KNEW was not the case! It is fascinating that there is a mechanical/physical model there.....
neurotransmitters again, I think..... |
All times are GMT -5. The time now is 03:37 AM. |
Powered by vBulletin Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
vBulletin Optimisation provided by
vB Optimise v2.7.1 (Lite) -
vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.