NeuroTalk Support Groups - High B6 the reason?

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High B6 the reason?

My neurologist called and said my blood work showed I had a B6 level of 110 and that this could explain my neuropathic symptoms. Im shocked! Could this be it? I was told to stop taking all vits and sups and get retested in 3 months prior to my appointment.

Please read the following.

I do think you should do this experiment, however. But be advised that B6 in the serum of the blood does not reflect accurately when high. It is the B6 in the cells that matters.

When blood is drawn sometimes red cells burst...creating false (factitious) highs. This is very common with potassium readings as well.

http://neurotalk.psychcentral.com/thread30724.html

http://neurotalk.psychcentral.com/sh...ght=vitamin+B6

This paper demonstrates that some people may have elevated levels when taking NO supplements:
http://www.ncbi.nlm.nih.gov/pubmed/16494569

What it suggests is the the conversion of pyridoxine to it's active form pyridoxal, is impaired, hence the pyridoxine accumulates.

B6 unlike some other B vitamins is stored in muscle tissue.
http://books.google.com/books?id=rXS...muscle&f=false

Also lab ranges were not developed on subjects taking vitamins.
Hence interpreting them is difficult and often not accurate.
If you are concerned, I'd get a better test with better results from Spectracell. The link is in one of the links I gave in this post.

So the bottom line? Do the experiment and stop supplements. Sit down and read your labels and see how much you actually consume. But you may find this is not going to impact you. Had it been a cause you would have had symptoms before your injury. Stay away from heat and hot tubs to allow healing of the
nerves.

In the past the actual patients with B6 damage took 500mg a day or more. Very few people do this today. (that was an old
treatment protocol for PMS in women).

Here is another link:
http://lpi.oregonstate.edu/infocente...ins/vitaminB6/

Quote:

Toxicity

Because adverse effects have only been documented from vitamin B6 supplements and never from food sources, safety concerning only the supplemental form of vitamin B6 (pyridoxine) is discussed. Although vitamin B6 is a water-soluble vitamin and is excreted in the urine, long-term supplementation with very high doses of pyridoxine may result in painful neurological symptoms known as sensory neuropathy. Symptoms include pain and numbness of the extremities and in severe cases, difficulty walking. Sensory neuropathy typically develops at doses of pyridoxine in excess of 1,000 mg per day. However, there have been a few case reports of individuals who developed sensory neuropathies at doses of less than 500 mg daily over a period of months. Yet, none of the studies in which an objective neurological examination was performed reported evidence of sensory nerve damage at intakes below 200 mg pyridoxine daily (24). To prevent sensory neuropathy in virtually all individuals, the Food and Nutrition Board of the Institute of Medicine set the tolerable upper intake level (UL) for pyridoxine at 100 mg/day for adults (see table below) (7). Because placebo-controlled studies have generally failed to show therapeutic benefits of high doses of pyridoxine, there is little reason to exceed the UL of 100 mg/day.