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Article: Insulin secretion and Antipsychotics (incl.Zyprexa)

Insulin Secretion and Psychotropic Drugs
Primary Psychiatry. 2006;13(12):26-27
Donald S. Robinson, MD

(download pdf)

OK, this is NOT how i have been "explaining it" indeed because it is NOT quite how i "understood it" from the diabetologist - almost backwards in fact? ... i suppose there had to be some misunderstanding but here's an intersting article that explains a few mechanisms.

i still don't frankly get the hunger but i think that has to do with your body not being able to burn sugar... i have read that being hungry a lot and thirsty (plus other signs, not that alone) happens during diabetes onset.... mind you i feel very non-credible right now so don't mind me. just read the article, or sections of it as you see fit.

waves

Thanks for the post waves, I will read this file later. :D

FYI - the two links are to the same information

the first link is an HTML page containing the full article.

the second link is the PDF of the same article.

i just thought some ppl might prefer one format over the other.

This is wonderful! I will have to come back to it a few times.

Good-Post:Waves,
I've read the article twice and have gotten what I could from it for now. I will read again.
This is my understanding:

Quote:

by inhibiting insulin secretion by ß cells.

1. Zyprexa (and others) interfere with the pacreas's ability to make insulin.
2. The body does not have enough insulin.
3. To make up for not having enough insulin, the body makes more insulin than it needs.
4. Too much insulin causes weight gain.

Quote:

Fluoxetine, sertraline, venlafaxine, and bupropion, on the other hand, have relatively low binding affinities for this receptor and a lesser liability for causing obesity during long-term use.8

Well, I am going to ask the pdoc about Zoloft tomorrow as it good for being weight neutral.

Mari

Quote:

Originally Posted by waves (Post 749509)

[
i still don't frankly get the hunger but i think that has to do with your body not being able to burn sugar... i have read that being hungry a lot and thirsty (plus other signs, not that alone) happens during diabetes onset.... mind you i feel very non-credible right now so don't mind me. just read the article, or sections of it as you see fit.

http://www.psycheducation.org/hormon...weightgain.htm

Waves,
This site says that Zyprexa stimulates "some of the stomach serotonin receptors that are thought to be responsible for appetite increase."

Also here talks about a wafer developed to absorb in the mouth and mostly bypass the stomach: http://www.ncbi.nlm.nih.gov/pubmed/17191265

Quote:

Partial sublingual absorption occurring with orally disintegrating olanzapine may bypass gastrointestinal metabolisation and hence lead to differences in metabolite versus parent compound ratios. However, the need arises to replicate the present study with a longer follow-up.

http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

Quote:

These findings suggest that adolescents gain less weight with OLZ ODT than OLZ SOT, possibly because the former formulation shortens the time of interaction with digestive serotonin receptors mediating satiety.

The first action for weight gain is in the stomach.
The second action for weight gain is in the pancreas.

Let me know if I mostly got this right.

M.

Quote:

Originally Posted by Mari (Post 749527)

Good-Post:Waves,
I've read the article twice and have gotten what I could from it for now. I will read again.
This is my understanding:
1. Zyprexa (and others) interfere with the pacreas's ability to make insulin.
2. The body does not have enough insulin.
3. To make up for not having enough insulin, the body makes more insulin than it needs.
4. Too much insulin causes weight gain.

Hi,
I'm still trying to work this out.
Zyprexa initially blocks the pancreas cells that make insulin. This is why having too little insulin causes more insulin:

http://www.ei-resource.org/illness-i...in-resistance/

Quote:

Insulin resistance is the name given to a condition in which, for a number of reasons, the body's cells become less sensitive to the effects of insulin. The body reacts to this situation by producing more insulin with the common result being an overproduction of insulin causing blood sugar levels to drop too low.
In this way, blood sugar levels swing from too high to too low.
This is often referred to as a "blood sugar rollercoaster". As well as the symptoms produced by the hypoglycemic state, the high levels of insulin themselves can have serious health consequences in the long term. The underlying mechanism by which insulin resistance occurs is due to the insulin receptor cells in the liver, adipose (fat) tissue and muscles, becoming less efficient as a result of chronic exposure to high levels of insulin.
This is the type of feedback mechanism that is at work in many body systems. If the levels of any chemical messenger such as hormones and neurotransmitters are chronically raised, the cells that they act on become less and less sensitive to them to avoid overstimulation.

I hope that I get this right. If I don't . . that's ok . . . because this stuff is explained poorly on the Internet for non-scientists.

M.

thanks so much for following up with all these tidbits Mari... so kind of you, esp when you are not doing so hot and computer either.

this is of immense help getting the puzzle pieces together. i don't know if you are right - sound right to me so far... tonight i got home late after pdoc, then had to do stuff for my mom - got free at 11.30pm SIGHH.... so, i will be back at a better time to follow up and read links.

anway, sending hugs along with my thanks. :)

~ waves ~