How LRRK2 mutations may cause Parkinson's
 

How mutations in a gene cause Parkinson's disease

http://www.sify.com/news/how-mutatio...0oaefgdbd.html

Scientists have found a way that mutations in a gene called LRRK2 may cause the most common inherited form of Parkinson's disease.

The study, conducted by researchers at Mount Sinai School of Medicine, shows that upon specific modification called phosphorylation, LRRK2 protein binds to a family of proteins called 14-3-3, which has a regulatory function inside cells. When there is a mutation in LRRK2, 14-3-3 is impaired, leading to Parkinson's....