New Publication on LDN
 

Check out this link posted on the NT Multiple Sclerosis forum by Sally C:

http://beforeitsnews.com/story/1051/...altrexone.html

Having read the article, which is very interesting, given that there are people here who have discussed LDN over more than a few years, it would be nice to see some discussion of this too! From a quick reading it would seem that there are two main areas that it is working on, cell proliferation and inflammation.
Relating to PD......?? And perhaps Braak?

Any takers?

Lindy, the first thing that comes to my mind is the possible connection between the efficacy of regular, vigorous (aerobic?) exercise, e.g.,forced, rapid bicycle pedaling for slowing PD progression and the resulting stimulation of endorphin production. The critical question would seem to be; How are endorphins involved in regulating the immune system, specifically pathways leading to neuro-inflammation?

Hi RLSmi,
Would you please explain why the article made the possible connection btwn vigorous exercise for slowing PD progression and the resulting stimulation of endorphin production come to mind? I started doing strenuous exercise in July and definitely feel better. (was exercising regularly before, but not as strenuously) Thanks, it's hard to decipher research articles. Lin

Hi Lin,
I am simply assuming that the well-documented stimulation of endorphin levels by strenuous exercise, and the effect of LDN to achieve a similar rise in the endorphin met-enkephalin demonstrated in Dr. Zagon's work, both result in an anti-inflammatory response by the immune system. This, in turn, assumes that PD is the result of damage to specific nervous system components by uncontrolled neuroinflammation.
The exact mechanism whereby such endorphins regulate/control the immune system remains a mystery to me.

Thanks for explaining. Appreciate your posts. Lin

Low dose dextromethorphan
 

It's been awhile since I posted here. I fell back in May and broke my hip (upper femor, long rod fixation) and have been recovering over the months. I stopped taking LDN about 9 months ago thinking it wasn't helping and too expensive to bother with. I've probably declined more rapidly but who knows. My neuro insists that I take 1.875 mg of Mirapex so I won't have to take as much Sinemet. It has a lot of side effects for me. I think that was part of the reason for my fall.

Anyway, here is a recent article on LD dextromethorphan, Dr. Hong is one of the authors.

http://www.sciencedirect.com/science...69996111002026

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord
Overall, our results reveal a novel protective effect of low dose DM in autoimmune CNS inflammation, and demonstrate that a possible mechanism of action is via inhibition of NADPH oxidase and decrease of CNS leukocytes infiltration. These exciting findings may provide useful information leading to a new, inexpensive strategy for treating MS.

Regards, Ashley