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Studies: Vitamin D low in psychiatric patients

Hi,
I was looking for the relationship of low Vitamin D and mental illness. I found these articles:

Is this D vitamin to worry about? Vitamin D insufficiency in an inpatient sample

http://informahealthcare.com/doi/abs...48670802345516

Quote:

Conclusion: Low levels of serum 25-OHD were found in this patient population.
These data add to the literature suggesting an association between vitamin D insufficiency and psychiatric illness, and suggest that routine monitoring of vitamin D levels may be of benefit given the high yield of clinically relevant findings.

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Low serum levels of 25-hydroxyvitamin D (25-OHD) among psychiatric out-patients in Sweden: Relations with season, age, ethnic origin and psychiatric diagnosis
http://www.sciencedirect.com/science...60076010001032

Quote:

Hence, the diagnoses that have been hypothetically linked to developmental (prenatal) vitamin D deficiency, schizophrenia and autism, had the lowest 25-OHD levels in this adult sample, supporting the notion that vitamin D deficiency may not only be a predisposing developmental factor but also relate to the adult patients’ psychiatric state. This is further supported by the considerable psychiatric improvement that coincided with vitamin D treatment in some of the patients whose deficiency was treated.

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Here is a complete Vitamin D article in PDF:
Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects
http://www.biomedcentral.com/content...-0003-7-50.pdf

Quote:

Additionally, a relationship between vitamin D deficiency and anxio-depressive disorders is likely since low serum 25(OH)D concentrations are closely associated with active mood disorders [70] and have been proposed as the missing link between seasonal changes in photoperiod and sea- sonal mood swings [70].
In line with this, one clinical trial supported the efficacy of vitamin D supplementation on mood disorders [108].
Finally, accounting for depression is of primary importance while exploring the involvement of vitamin D-related cognitive functioning in locomotor function as depressed people are usually less active and loose muscle mass as well as sensorimo- tor performance [70].

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Researchers have not focused much on anxiety:
I found one promising reference on Anxiety that I do not have access too via Google Scholar.

Quote:

Kalueff AV, Lou YR, Laaksi I, Tuohimaa P: Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport 2004, 15:1271-1274.

I was out side today for almost an hour from 3:00-4:00 on a cloudy day. Later I felt less anxious than I normally do.
I will try to go out earlier in the day around noon (HA!) on Tuesday.

M

Quote:

Originally Posted by Mari (Post 833633)

Hi,

Researchers have not focused much on anxiety:
I found one promising reference on Anxiety that I do not have access too via Google Scholar.

HI,

I found the abstract to the article:
http://www.ncbi.nlm.nih.gov/pubmed/15167547
Increased anxiety in mice lacking vitamin D receptor gene.

Quote:

Vitamin D is a steroid hormone with many important functions in the brain, mediated through the vitamin D nuclear receptor. Numerous human and animal data link vitamin D dysfunctions to various behavioural disorders.

To examine this problem, we studied whether genetic ablation of vitamin D receptors in mice may be associated with altered emotional behaviours. Here we show that the receptor-deficient mice demonstrate increased anxiety-like behaviours when subjected to a battery of behavioural tests. These studies suggest that vitamin D and its receptors are an important factor in the brain, whose imbalance may significantly affect emotional behaviour.

Thanks Mari

...for all of these references. i might need to use them.

some time ago (like a year) i sent my pdoc one or more exerpts showing studies of low vitamin D in adults with major depression, post-partum depression, and SAD.

reason being, i'm not sure my mdoc will collaborate on scripting the amount i may need through the state. i am still ramping up, so we'll see. anyway, i was "prepping" myself to try to persuad pdoc to script it for me, even if i have to pay out of pocket. the script stuff isn't terribly expensive.

i cannot get high dose pills OTC here, tops being 300IU, so i'd have to take like 9 pills per day... just to get a measly 2100 IU. and that stuff IS more expensive. besides other complications on acquiring it.

REMINDER to anyone reading ... re: types of Vitamin D:

where i live, all Vit D i(prescription and OTC) is Vitamin D3 - cholecalciferol.

In the US only Vit D2 is scripted which is much less effective. But you can get cheap Vitamin D3, OTC. That's what you want.

If you are anywhere else, or if you are unsure, check before buying that you are getting D3 and NOT D2.

~ waves ~

brain health and vitamin D3

This was written a year ago. Has links and videos.
Brain Health: Vitamin D.
Did you know there are some people who desperately need higher levels of vitamin D than others? Some people genetically are different and don't have as good cell receptors for the hormone (vitamin D is actually a hormone). My doctor said the only way to know for sure if your level is enough is to know how much gets inside the cell. So before, we used to rely on serum level, and now there is an even better test to test the amount inside. He said there is a genetic test for it, too (VDR alleles). I didn't have the genetic test. I did have the test for whether I have enough vitamin D on the inside of my cells.

I was low on vit d and my doctor believes that is one reason for my bone break in feb. needed for calcium uptake and bone formation. which I also showed osteopenia on the bone density scan.
I think my moms doctor told her that she stopped testing for vit d levels because they were all low so she just prescribes 2,000 units for all her patients.
bizi

Quote:

Originally Posted by waves (Post 833648)

I am nosy, were is it that limits the availability so severely?

European Union limits therapeutic dosages for supplements:

http://nutrientscure.wordpress.com/2...in-april-2011/

This threat to control dosages of common supplements has been ongoing for a long time now.

I am not sure how extensive it is, or if it has been blocked once again?

Dear MrsD and Pabb,

i have NO idea where that blogger gets their info but it certainly doesn't apply in this country, and I am certainly living in the EU.

:confused:

i can assure you that the EU allows distribution of herbal remedies, herbal supplements, as well as vitamins and minerals, all OTC. Where i live items considered "therapeutic" (including drugs or other) are only available in pharmacies or specialized areas that have a pharmacist. This is a not new thing here; it predates the existence of the EU.

The only thing i can think of is that some European countries may have offered these items in supermarkets or general stores, like in the US, and that there may have been EU restrictions placed on distribution channels - the blog might then refer to the stripping of "common" shelves such as supermarkets.

If, in the blogger's country, OTC supplements et al. have been stripped from pharmacy shelves, i assure you that is not per EU regulation. it would have to be specific to that country.

What is becoming more stringent per EU regulation, are the rules regarding the content and labeling - standardization, quantification, qualification of the contents of herbal remedies and such as (for instance) echinacea.

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In one way or another, i will be able to take the vitamin D in quantities i want, be it by eating lots of pills, or by prescription but out of pocket (preferable and cheaper).

~ waves ~

The European Union "scare" has been reported here since 2002 or thereabouts.

There is a similar bill in our legislature also that is similar.

It is very difficult to separate the hysteria from the facts.

It was my impression that B12 in 1mg doses and above would be controlled, so Vit D would also be in that category. We in the States don't always get reliable information about what is going on in Europe. Some of our media are fear mongers, and some not.