Articles, Abstracts and News Reports on TS
Haiqun Lin, Liliya Katsovich, Musie Ghebremichael, Diane B. Findley, Heidi Grantz, Paul J. Lombroso, Robert A. King, Heping Zhang, James F. Leckman (2007)
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder Journal of Child Psychology and Psychiatry 48 (2), 157–166. doi:10.1111/j.1469-7610.2006.01687.x http://www.blackwell-synergy.com/doi...0.2006.01687.x Quote:
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Abstract - whole genome screen
Am J Hum Genet. 2007 Feb;80(2):265-72.
Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families. Tourette Syndrome Association International Consortium for Genetics. Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken for TD. The sample analyzed includes 238 nuclear families yielding 304 "independent" sibling pairs and 18 separate multigenerational families, for a total of 2,040 individuals. A whole-genome screen with the use of 390 microsatellite markers was completed. Analyses were completed using two diagnostic classifications: (1) only individuals with TD were included as affected and (2) individuals with either TD or chronic-tic (CT) disorder were included as affected. Strong evidence of linkage was observed for a region on chromosome 2p (-log P = 4.42, P = 3.8 x 10(-5) in the analyses that included individuals with TD or CT disorder as affected. Results in several other regions also provide moderate evidence (-log P >2.0) of additional susceptibility loci for TD. PMID: 17304708 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum |
Abstract - Dopaminergic dysfunction in frontal lobe
J Neurol Sci. 2007 Mar 2; [Epub ahead of print]
Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis. Yoon DY, Gause CD, Leckman JF, Singer HS. Department of Neurology, Johns Hopkins University School of Medicine, Harriett Lane Outpatient Building, 200 N. Wolfe Street, Suite 2158, Baltimore, MD, USA. Frontal-subcortical abnormalities have been implicated in the pathophysiology of Tourette syndrome (TS). The goal of this study was to more extensively evaluate a possible underlying neurochemical abnormality in frontal cortex. Postmortem brain tissue from frontal and occipital regions (Brodmann's areas 4, 6, 9, 10, 11, 12, and 17) from three TS patients and three age-and sex-matched controls were analyzed by semiquantitative immunoblotting. Relative densities were measured for a variety of neurochemical markers including dopamine (D1, D2), serotonin (5HT-1A), and alpha-adrenergic (alpha-2A) receptors, the dopamine transporter (DAT), a monoamine terminal marker (vesicular monoamine transporter type 2, VMAT-2), and vesicular docking and release proteins (VAMP-2, synaptotagmin, SNAP-25, syntaxin, synaptophysin). Data from each TS sample, corrected for actin content, was expressed as a percentage value of its control. Results identified consistent increases of DAT and D2 receptor density in five of six frontal regions in all three TS subjects. D1 and alpha-2A receptor density were increased in a few frontal regions. These results support the hypothesis of a dopaminergic dysfunction in the frontal lobe and a likely role in the pathophysiology of TS. PMID: 17337006 [PubMed - as supplied by publisher] http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum |
Article- Discover magazine
although this article specifically deals with autism...it has much of interest and so I felt it worth posting here too related to ASD
http://discovermagazine.com/2007/apr...tart:int=0&-C= |
Genomics
http://www.sciencedirect.com/science...c57ec46e02d5e2
Genomics. 2003 Jul;82(1):1-9. Cntnap2 is disrupted in a family with gilles de la tourette syndrome and obsessive compulsive disorder Verkerk AJ, Mathews CA, Joosse M, Eussen BH, Heutink P, Oostra BA; Tourette Syndrome Association International Consortium for Genetics. _________________ http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum Eur J Hum Genet. 2007 Mar 28 Disruption of the CNTNAP2 gene in a t(7;15) translocation family without symptoms of Gilles de la Tourette syndrome. Belloso JM, Bache I, Guitart M, Caballin MR, Halgren C, Kirchhoff M, Ropers HH, Tommerup N, Tumer Z. Quote:
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Neuropsychologia. 2007 Apr 5;
Speeded processing of grammar and tool knowledge in Tourette's syndrome. Walenski M, Mostofsky SH, Ullman MT. http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum Quote:
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Quality of Life
Interesting...
J Clin Child Adolesc Psychol. 2007 Jun;36(2):217-27. Quality of Life in Youth With Tourette's Syndrome and Chronic Tic Disorder. Storch EA, Merlo LJ, Lack C, Geffken GR, Goodman WK, Murphy TK. Department of Psychiatry and Pediatrics, University of Florida. http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum Quote:
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These two are not specifically about Tourette's Syndrome but they are of interest.
The 2nd one regarding RLS is also of interest as quite a lot of people have Restless Leg Syndrome as well as their Tics or have members in their families who have RLS as well. [It fits in with the posts regarding OC behaviours or even Secondary causes of Tics or Tourettism.] So, just some things in the news of interest... http://www.sciencedaily.com/releases...0615110252.htm from Science Daily Source: Mayo Clinic Date: June 15, 2007 Researchers Use 'Genomic Pathway' To Predict Parkinson's <snipped article> Quote:
Dopaminergic Agonists Linked to Compulsions in RLS Medscape Medical News 2007 www.medscape.com/viewarticle/558519 Registration required Caroline Cassels Quote:
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Worth a read.
Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics: AHRQ Executive Summary
http://effectivehealthcare.ahrq.gov/...nal_Report.pdf Full Text pdf This is very long, but worth reading if you're interested. Just use the search feature to highlight keywords in the file e.g. Tourette's syndrome or Autism or PTSD etc.. from Medscape Medical News 07/06/2007 Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics: AHRQ Executive Summary http://www.medscape.com/viewarticle/559169_1 |
Deep Brain Stimulation
PubMed Abstract
Curr Opin Neurol. 2007 Aug;20(4):470-6. Surgery for other movement disorders: dystonia, tics. Hamani C, Moro E. Quote:
Curr Neurol Neurosci Rep. 2007 Jul;7(4):278-89. Limbic, associative, and motor territories within the targets for deep brain stimulation: potential clinical implications. Sudhyadhom A, Bova FJ, Foote KD, Rosado CA, Kirsch-Darrow L, Okun MS. Quote:
http://www.neurology.org/cgi/content/full/68/2/85 NEUROLOGY 2007;68:85 © 2007 American Academy of Neurology January 9 Highlight and Commentary Deep brain stimulation for a teen with tics? Donald L. Gilbert, MD, MS Quote:
Tourette’s syndrome and deep brain stimulation J L Houeto, C Karachi, L Mallet, B Pillon, J Yelnik, V Mesnage, M L Welter, S Navarro, A Pelissolo, P Damier, B Pidoux, D Dormont, P Cornu and Y Agid http://www.neurology.org/cgi/content...e2=tf_ipsecsha NEUROLOGY 2006;66:E12 NeuroImages Hemi tics and deep brain stimulation Catherine L. Gallagher, MD, P. Charles Garell, MD and Erwin B. Montgomery, Jr, MD http://www.touchbriefings.com/pdf/2785/tipuaziz.pdf Deep Brain Stimulation—Which Patients and When? |
PubMed Abstract
J Intellect Disabil Res. 2007 Aug;51(Pt 8):620-4. An individual with Gilles de la Tourette syndrome and Smith-Magenis microdeletion syndrome: is chromosome 17p11.2 a candidate region for Tourette syndrome putative susceptibility genes? Shelley BP, Robertson MM, Turk J. Quote:
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GABAergic circuits
PubMed Abstract
Clin Genet. 2007 Jul;72(1):1-8. Development of cortical GABAergic circuits and its implications for neurodevelopmental disorders. Di Cristo G. Quote:
Full Text available |
Development of distinct control networks through segregation and integration
PubMed Abstract
Proc Natl Acad Sci U S A. 2007 Aug 6; [Epub ahead of print] Development of distinct control networks through segregation and integration. Fair DA, Dosenbach NU, Church JA, Cohen AL, Brahmbhatt S, Miezin FM, Barch DM, Raichle ME, Petersen SE, Schlaggar BL. Quote:
http://www.pnas.org/cgi/reprint/0705843104v1 |
Olanzapine (Zyprexa)
Olanzapine (Zyprexa)
PubMed Abstract Psychiatr Prax. 2007 Jul;34(5):253-4. [Gilles-de-la-Tourette Syndrome as a Tardive Dyskinesia.] [Article in German] Kozian R, Friederich M. Asklepios-Fachklinik Stadtroda. Quote:
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Deep Brain Stimulation and TS - TSA-USA
Medical News Today article...
Neurology / Neuroscience News Article Date: 07 Aug 2007 http://www.medicalnewstoday.com/articles/78872.php Deep Brain Stimulation And Tourette Syndrome Quote:
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TSA-USA Statement: Deep Brain Stimulation and Tourette Syndrome Following is a statement from TSA Medical and Scientific Advisors. http://www.tsa-usa.org/news/DBSStatement.htm (I notice this Statement has been updated 8/2007) ____________________________ PubMed Abstract Mov Disord. 2006 Nov;21(11):1831-8. Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome. Mink JW, Walkup J, Frey KA, Como P, Cath D, Delong MR, Erenberg G, Jankovic J, Juncos J, Leckman JF, Swerdlow N, Visser-Vandewalle V, Vitek JL; Tourette Syndrome Association, Inc. Department of Neurology, University of Rochester, Rochester, New York, USA. Quote:
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Validity of large-deformation high dimensional brain mapping of the basal ganglia
PubMed Abstract
Psychiatry Res. 2007 Feb 28;154(2):181-90. Epub 2007 Feb 7. Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndrome. Wang L, Lee DY, Bailey E, Hartlein JM, Gado MH, Miller MI, Black KJ. Quote:
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Time trends in reported diagnoses of childhood neuropsychiatric disorders:
PubMed Abstract
Arch Pediatr Adolesc Med. 2007 Feb;161(2):193-8. Time trends in reported diagnoses of childhood neuropsychiatric disorders: a Danish cohort study. Atladottir HO, Parner ET, Schendel D, Dalsgaard S, Thomsen PH, Thorsen P. North Atlantic Neuro-Epidemiology Alliances at Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark. Quote:
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Tic symptom profiles from two genetically isolated populations
PubMed Abstract
Biol Psychiatry. 2007 Feb 1;61(3):292-300. Epub 2006 Apr 11. Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populations. Mathews CA, Jang KL, Herrera LD, Lowe TL, Budman CL, Erenberg G, Naarden A, Bruun RD, Schork NJ, Freimer NB, Reus VI. Department of Psychiatry, University of California, San Diego, La Jolla, California 92093-0810, USA. Quote:
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I am going to digest this one slowly Lara! thank you for posting that...lots to chew on huh
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Hi! I'm thinking you mean the "time trends" one from Denmark? I'm running out of time right now, but was looking for the full text articles from that one and also the genetic population differences one. Will post them here shortly. The one from Denmark is very interesting. Look forward to reading more about that. |
Hi Lara...yes LOl I didnt realise you were posting more so should have quoted it....
it is this one very interesting |
Thanks! More awake now. :) Breakfast helps. I'd browsed some of these I've posted months ago, but never got around to actually reading them or posting them.
I didn't see the link to free Full Text earlier. Full Text at http://archpedi.ama-assn.org/cgi/content/full/161/2/193 Time Trends in Reported Diagnoses of Childhood Neuropsychiatric Disorders A Danish Cohort Study Hjördís Ósk Atladóttir, MB; Erik T. Parner, MSc(Stat), PhD; Diana Schendel, PhD; Søren Dalsgaard, MD, PhD; Per Hove Thomsen, DMSc; Poul Thorsen, MD, PhD Arch Pediatr Adolesc Med. 2007;161:193-198 |
"Breakthrough" Dopamine Supersensitivity & Antipsychotic Treatment Failure over Time
http://www.jneurosci.org/cgi/content...act/27/11/2979
The Journal of Neuroscience, March 14, 2007, 27(11):2979-2986; doi:10.1523/JNEUROSCI.5416-06.2007 "Breakthrough" Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time Anne-Noël Samaha, Philip Seeman, Jane Stewart, Heshmat Rajabi, and Shitij Kapur Quote:
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Frontal-subcortical circuitry and behavior.
PubMed Abstract
Dialogues Clin Neurosci. 2007;9(2):141-51. Frontal-subcortical circuitry and behavior. Bonelli RM, Cummings JL. Department of Psychiatry, Graz Medical University, Auenbruggerplatz 31, 8036 Graz, Austria. Quote:
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Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.
PubMed Abstract ahead of print
Mov Disord. 2007 Aug 20; [Epub ahead of print] Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome. Behen M, Chugani HT, Juhász C, Helder E, Ho A, Maqbool M, Rothermel RD, Perry J, Muzik O. Quote:
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Durability, Negative Impact, and Neuropsychological Predictors of Tic Suppression
I find this one really strange.
Note this study contained 13 children only. I wonder if the same results would have been found if the participants had been adults. Frankly I find it very difficult to believe that periods of tic suppression do not result in a rebound. Waiting now to read the full article when I can. PubMed abstract ahead of print J Abnorm Child Psychol. 2007 Aug 24; [Epub ahead of print] Durability, Negative Impact, and Neuropsychological Predictors of Tic Suppression in Children with Chronic Tic Disorder. Woods DW, Himle MB, Miltenberger RG, Carr JE, Osmon DC, Karsten AM, Jostad C, Bosch A. Quote:
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Interesting
PubMed
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http://www.nlm.nih.gov/medlineplus/d...r/a601209.html Quote:
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Mycoplasma pneumoniae Infection and OCD: A Case Report.
PubMed
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Vomiting and tics
PubMed
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In Harms Way
downloadable info on Toxicology and Neurological Development
http://psr.igc.org/ihw-report.htm#ihwRptDwnld |
The Role of Heredity in Mood Disorders
as depression is something many people with TS deal with, I thought this might be helpful here
http://psychcentral.com/news/2008/03...ders/2038.html |
Education Strategies & Advocacy
just recently I have heard from many parents who are struggling to get needed 504 or IEP accomodations for their TS child(ren)
remember that TS is classified under IDEA under the Americans with Disabilities Act as "other health impaired" and so the accommodations are entitled by Law!! The TSA has really helpful info education strategies http://www.tsa-usa.org/educ_advoc/ed...strat_main.htm education advocacy http://www.tsa-usa.org/educ_advoc/ed...cacy_main.html |
"Parkinson's disease, Tourette syndrome, and the changing nature of depression"
PubMed
CNS Spectr. 2008 Aug;13(8):643-4.Click here to read Links Parkinson's disease, Tourette syndrome, and the changing nature of depression: the dog days of summer. Hollander E. PMID: 18704019 [PubMed - indexed for MEDLINE] Cnsspectrums Parkinson’s Disease, Tourette Syndrome, and the Changing Nature of Depression: The Dog Days of Summer Eric Hollander, MD CNS Spectr. 2008;13(8):643-644 Quote:
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Blood Brain Barrier
I may delete this in the morning. Haven't finished reading it but I thought I'd post it here for the moment as it's certainly topical for some
- Blood Brain Barrier, Rheumatic Fever, Sydenham's Chorea, Anxiety, tics, ocd. It's like a timewarp. International Journal of Neuropsychiatric Medicine Anxiety Disorders and Rheumatic Fever: Is There an Association? André Augusto Anderson Seixas, MD, Ana Gabriela Hounie, MD, PhD, Victor Fossaluza, BS, Mariana Curi, MSc, Pedro Gomes Alvarenga, MD, Maria Alice De Mathis, BS, Maria Eugênia De Mathis, BS, Homero Vallada, MD, PhD, David Pauls, PhD, Carlos Alberto de Bragança Pereira, PhD, and Eurípedes Constantino Miguel, MD, P CNS Spectr. 2008;13(12):1039-1042,1044-1046 |
Magnesium and B6
Med Clin (Barc). 2008 Nov 22;131(18):689-92.
An open study evaluating the efficacy and security of magnesium and vitamin B(6) as a treatment of Tourette syndrome in children. [Article in Spanish] PubMed Article |
'The Diagnosis of Tourette's Syndrome: Communication and Impact.'
PubMed
Clin Child Psychol Psychiatry. 2009 Jan;14(1):13-23. The Diagnosis of Tourette's Syndrome: Communication and Impact. Rivera-Navarro J, Cubo E, Almazán J. Salamanca University, Spain. <snipped abstract> Quote:
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Charcot's contribution to the study of Tourette's syndrome
PubMed
Charcot's contribution to the study of Tourette's syndrome We review the history of Tourette syndrome, emphasizing the contribution of Jean-Martin Charcot. Teive HA, Chien HF, Munhoz RP, Barbosa ER. Movement Disorders Unit, Hospital de Clínicas, Hospital de Clínicas, Federal University of Paraná, Curitiba PR, Brazil. __________ Full text... Associação Arquivos de Neuro-Psiquiatria Arquivos de Neuro-Psiquiatria Print ISSN 0004-282X Arq. Neuro-Psiquiatr. vol.66 no.4 São Paulo Dec. 2008 Charcot's contribution to the study of Tourette's syndrome Hélio A.G. Teive; Hsin Fen Chien; Renato Puppi Munhoz; Egberto Reis Barbosa Movement Disorders Unit, Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba PR, Brazil Movement Disorders Clinic, Department of Neurology, Hospital das Clínicas, University of São Paulo, São Paulo SP, Brazil |
Neuropsychiatric Disorders Associated With Streptococcal Infection
J Am Acad Child Adolesc Psychiatry. 2008 Aug 21.
Neuropsychiatric Disorders Associated With Streptococcal Infection: A Case-Control Study Among Privately Insured Children. Leslie DL, Kozma L, Martin A, Landeros A, Katsovich L, King RA, Leckman JF. Dr. Leslie is with the Department of Health Administration and Policy, Medical University of South Carolina; Ms. Kozma is with the Department of Chemistry, Yale University; and Drs. Martin, Landeros, King, and Leckman and Ms. Katsovich are with the Child Study Center, Yale University School of Medicine. Quote:
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Journal of the American Academy of Child & Adolescent Psychiatry: October 2008 - Volume 47 - Issue 10 - pp 1166-1172 doi: 10.1097/CHI.0b013e3181825a3d New Research |
Tic disorders and ADHD - from Tourette Syndrome International Database Consortium ...
PubMed
Eur Child Adolesc Psychiatry. 2007 Jun;16 Suppl 1:15-23.
Tic disorders and ADHD: answers from a world-wide clinical dataset on Tourette syndrome. Freeman RD; Tourette Syndrome International Database Consortium. Quote:
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Streptococcal infection and exacerbations of childhood tics and OC symptoms
PubMed Abstract
Pediatrics. 2008 Jun;121(6):1188-97.
Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study. Kurlan R, Johnson D, Kaplan EL; and the Tourette Syndrome Study Group. University of Rochester School of Medicine, |
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