Identification of common genetic modifiers of neurodegenerative diseases
 

http://www.biomedcentral.com/content...2164-13-71.pdf
RESULTS:
We carried out an integrated analysis using C. elegans as the baseline model organism since this is the most widely studied in this context. Combination of data from 28 published studies using small to large scale screens in all three small model organisms gave a total of 950 identifications of genetic regulators. Of these 624 were separate genes with orthologues in C. elegans. In addition, 34 of these genes, which all had human orthologues, were found to overlap across studies. Of the common genetic regulators some such as chaperones, ubiquitin-related enzymes (including the E3 ligase CHIP which directly links the two pathways) and histone deacetylases were involved in expected pathways whereas others such as the peroxisomal acyl CoA-oxidase suggest novel targets for neurodegenerative disease therapy

browsing the raw data
 

Thankyou for posting this thread. I know its a lot to ask but would you simplify and interpret this information a bit further please?
I am wondering what the name (for purpose of "browsing the raw data" on the 23andme site )of the gene(s) (would they include D. melanogaster (CG1555) and C. elegans (R07B7 ?)and their associated variants that detoxify toxins from the liver are - and, if, one posseses such does this indicate supplementation to compensate (or would uptake mechanisms not be present anyway....) and what that would be.

With kind regards,
sharilyn

eipgenetics
 

Hi Moondaughter, Your request defines my motive for posting this. I am in hopes someone with more skills, access to the full text of the study report and time would determine just what genes were involved and would also have knowledge of epigenetic substances/molecules that could be used to impact these genetic variations ( epigenetic molecules can stick onto DNA segments and prevent sequence parts of the DNA from being read, which can lead to genetic changes. )
I will also try to discover the answers, though it will take me lots of time.
ANyone out there able to help in deciphering this study? thanks, madelytn

HI Madelyn, :)

Please, no need to take my request on - i had a feeling when i made it i was asking alot- heavens knows we have plenty to carry right now and besides i think its better to focus on epigenetics anyway-be solution rather than cause(why look for the match that caused the forest fire?) oriented.

md