Husband with PD, has burning skin sensation
 

HELP!
My husband was diagnosed with PD in 2001. Was started on Mirapex, and did well with that then Amantadine was added and our world fell apart quickly due to side effects.
He is now taking Stalevo 150 mg 4 x a day, Sinemet 25/100 4 x a day, Seroquel 100 mg @ bedtime, Zoloft 50mg @ bedtime, Klonopin 1 mg @ bedtime for PD. He is also taking Prilosec 20 mg 2 x a day, Vytorin 40mg 1 x a day, Cardura 4 mg 1 x a day.
He has been experiencing a burning prickly sensation in his skin for a couple of years now. It is progressively getting worse to the point it is almost incapacitating him. His Neuro Dr here has dx'd him with hallucinations due to PD & Med's as well as his Neuro Dr @ Mayo Clinic in Jacksonville, Fl. The only thing we are doing is adjusting his Seroquel & Zoloft, but it has not had any effect on him at all. He is at the end of his rope, his skin feels like it is on fire at times, and that things are contaminating him.
My question is has anyone in the forum heard of or dealt with this kind of issue, and do you have any help or suggestions?

Hi and welcome to NeuroTalk! I've posted a link to the Parkinson's Forum. You might want to post your intro there, too.

http://neurotalk.psychcentral.com/forum34.html

I see two major culprits for nerves that are causing discomfort:

1) Prilosec affects absorption of Vit B12. This can be tested for and if lower than 400 in US should be supplemented.
40mg a day is a high dose besides.
(other nutrients are affected by acid blocking drugs...
calcium, magnesium, folate, iron, zinc, B12, are what we know so far... and protein digestion is impaired as well. So some amino acids may be lacking).

2) Vytorin contains a statin, and statins are known causes of neuropathy. The statin in Vytorin is Zocor one of the most lipophilic (fat soluble) statins... and this one enters the brain and other nerves the most easily.

Burning skin is a form of peripheral neuropathy.

I think these things are in addition the to PD... you can read more at our PN forum:

http://neurotalk.psychcentral.com/forum20.html

Using a good drug checker:

http://www.drugs.com/interactions-ch...-499,1979-1274

This interaction is between Cardura and Seroquel.

the following is for Cardura, Seroquel, Sinemet:
http://www.drugs.com/interactions-ch...9-1274,515-250

Nice to meet you!!