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-   -   Acetyl L-Carnitine (https://www.neurotalk.org/peripheral-neuropathy/168284-acetyl-carnitine.html)

Shezian 04-17-2012 03:10 AM

Acetyl L-Carnitine
 
How is this useful for PN? What does it do?

So many questions going through my head.

Sue

RideOn 04-17-2012 03:52 AM

Sue, if you decide to get any supplements I can recommend iherb. I ordered a bunch of stuff from them and it got here quicker on standard shipping and cheaper than my order from a supplier in Qld.

mrsD 04-17-2012 05:26 AM

Acetyl carnitine is for people with suspected mitochondrial damage.

It is used in chemo damage and damage from the drugs to treat HIV positive patients. Some drugs damage mitochondria and so giving supplements for this can help.

If you are interested here is a link to more information.
http://neurotalk.psychcentral.com/post653568-5.html

Carnitine declines with age...so older patients may not make enough for their needs, since our body makes it for us.
The acetyl form is better absorbed than the plain carnitine.

This is our thread on mitochondria:
http://neurotalk.psychcentral.com/sh...t=mitochondria

Shezian 04-17-2012 07:10 AM

Ride on- what did you order?

MrsD- do you think it's worth giving them a shot? I havent, had chemo or anything like that?

Sue:)

mrsD 04-17-2012 11:49 AM

Carnitine is not toxic, and for the most part easy to tolerate.

It can be expensive however. If you want to try it, do it.

Start at 500mg a day and increase 500mg increments weekly to 2 grams if you need to. Give it 3 months. If nothing, then that is a sign you probably don't need it. Take in divided doses, as it
is not well absorbed in the GI tract. The acetyl form is a bit more absorbed so is recommended mostly now.

I think stopping the wine for now, would be a first step.
See what happens. All those sulfites! If you went to a doctor that would be the first recommendation, in fact.

Sallysblooms 04-17-2012 11:56 AM

My doctor has me taking Carniclear, liquid. It is good. Great for my Chronic Fatigue Syndrome and nerves also. This has B12 and B5 also.

http://www.rockwellnutrition.com/Car...3.html#tablist

mrsD 04-17-2012 03:40 PM

Quote:

Originally Posted by Sallysblooms (Post 870837)
My doctor has me taking Carniclear, liquid. It is good. Great for my Chronic Fatigue Syndrome and nerves also. This has B12 and B5 also.

http://www.rockwellnutrition.com/Car...3.html#tablist

That liquid is quite expensive... Carnitine is not well absorbed orally, even in liquid form.

Quote:

L-Carnitine Supplements

While bioavailability of L-carnitine from the diet is quite high (see Dietary L-Carnitine), absorption from oral L-carnitine supplements is considerably lower. According to one study, bioavailability of L-carnitine from oral supplements (0.5-6 gram dosage) ranges from 14%-18% of the total dose (5). Less is known regarding the metabolism of the acetylated form of L-carnitine, acetyl-L-carnitine (ALCAR); however, bioavailability of ALCAR is thought to be higher than L-carnitine. The results of in vitro experiments suggest that ALCAR is partially hydrolyzed upon intestinal absorption (10). In humans, administration of 2 grams of ALCAR per day for 50 days increased plasma ALCAR levels by 43%, suggesting that some acetyl-L-carnitine is absorbed without hydrolysis or that L-carnitine is reacetylated in the enterocyte (5).
from http://lpi.oregonstate.edu/infocente...uts/carnitine/

Sallysblooms 04-17-2012 04:18 PM

It has been very good for me. Brain fog with CFS is completely gone. Most people with CFS have a bad problem with it. So good for the brain in many ways. My doctors are so knowledgeable thankfully. I hate to think about how ill I would still be without them.

RideOn 04-17-2012 10:41 PM

Quote:

Originally Posted by Shezian (Post 870745)
Ride on- what did you order?

MrsD- do you think it's worth giving them a shot? I havent, had chemo or anything like that?

Sue:)

Sue, I probably went a bit overboard but I haven't had time to read everything in this forum and I am a bit confused. Based on comments by mrsD and using recommendations on this thread and with a nothing to lose approach I ordered:
methyl B12 (Dr's Best)
B1 Benfionate (Dr's Best)
R-Lipoic Acid (Dr's Best)
Acetyl L-Carnitine
CQ10
Stabilised vit C
Flax seed
Milk thistle

I also bought the following locally.
Treos B plus
Folic acid, not sure if I'm taking the right type
Fish Oil

I can't tell you the strengths as I'm away from home at the moment so I can't check. I'm progressively going to try all of these and watch for results. I've decided that I need to get serious about keeping a diary of what I'm doing and how I feel.

Steve :)

Shezian 04-18-2012 04:17 AM

Wow what a list. If you don,t get relief from those, then l don,t know what will help!

Haven't got anything yet my blood test doesn't,t show l am deficient in anything.

Have you had a blood test yet?

Sue


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