Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease?
Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases.
http://onlinelibrary.wiley.com/doi/1...25020/abstract Abstract Background: Despite clinicopathological evidence that Parkinson's disease (PD) may begin in peripheral tissues, identification of premotor Parkinson's disease is not yet possible. Alpha-synuclein aggregation underlies Parkinson's disease pathology, and its presence in peripheral tissues may be a reliable disease biomarker. Objective: We sought evidence of alpha-synuclein pathology in colonic tissues before the development of characteristic Parkinson's disease motor symptoms. Methods: Old colon biopsy samples were available for three subjects with PD. Biopsies were obtained 2-5 years before PD onset. We performed immunohistochemistry studies for the presence of alpha-synuclein and Substance P in these samples. Results: All subjects showed immunostaining for alpha-synuclein (two, five and two years before first motor Parkinson's disease symptom). No similar alpha-synuclein immunostaining was seen in 23 healthy controls. Staining of samples for substance P suggested colocalization of alpha-synuclein and substance P in perikarya and neurites. Conclusions: This is the first demonstration of alpha-synuclein in colon tissue prior to onset of PD. Additional study is required to determine whether colonic mucosal biopsy may be a biomarker of premotor PD |
wanted to add this information from the MJFF blog
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Hi there,
I just went to a research symposium for the mj fox foundation at yale this week. Did you speak there? Quote:
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research roundtable...
Yes...I was on the panel at the MJFF Roundtable in New Haven along with two PhD colleagues, a clinical neurologist and a scientist from Pfizer. I hope you found the session useful.
Debi |
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