Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of
 

Neurochem Res. 2007 Mar 31; [Epub ahead of print]

Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of
Healthy Rat.


Mokni M, Elkahoui S, Limam F, Amri M, Aouani E.


Laboratoire de Physiologie de la Nutrition, Faculte des Sciences de
Tunis, Campus Universitaire El Manar II, 2092, Tunis, Tunisia.


We have studied the effect of resveratrol on lipoperoxidation and
antioxidant enzyme activity level in the brain of healthy rats. When
intraperitoneally administered, resveratrol significantly and dose
dependently decreased brain malondialdehyde level. Resveratrol also
increased in a dose-dependent way brain superoxide dismutase, catalase
and peroxidase activities. Optimal effect on antioxidant enzyme and
lipoperoxidation products were obtained with resveratrol concentration
of 12.5 mg/kg body wt. Native polyacrylamide gel electrophoresis
analysis of antioxidant isoenzymes revealed that resveratrol up
regulated at least two acidic superoxide dismutase isoforms called
A(1) and A(2), two basic isoforms called B(1) and B(2). Resveratrol
also up regulated two catalase isoforms and a broad peroxidase band
corresponding to several isoforms. All these findings suggest that
resveratrol is able to cross the blood brain barrier and exerts potent
antioxidant features. Resveratrol also exerts neuroprotective
properties by up regulating several detoxifying enzymes, most of which
are iron proteins.


PMID: 17401679 [PubMed - as supplied by publisher]

(healthy rats receive brain protection from resveratrol-- though the administration intraperiotneally does not sound very appealing...rats do not like wine?? i know, they would have to drink too much wine to obtain the benefits of resveratrol)