MB again
 

Following up to Rick's post this week about MB and neuroprotective potential, check out this article where the encephelopathy of folks getting a cancer drug (caused by the drug in 10-15% of people taking the drug, that's quite a side effect) was resolved: http://www.nature.com/bjc/journal/v8.../6690917a.html

I've also read on some other non-PD forums that MB helps with CFS. The question I currently have is if one wanted to white rat this, would you just mix it up and drink it, like many are doing, or go the injection route, which I have read can cause a righteous skin irritation depending on how deep the needle goes?

Regardless, this is another validation of MB's effects on the brain, and it sounds like it's all good so far...

Lurking-
My immediate response is why take the risk? Since we have reason to believe that the oral route is both safe and effective, it would seem best to start there. I had been thinking that the extreme upper range would be when blue urine was noted since that has been explored by schoolboys and seems to be far less than the "swimming pool" dilutions mentioned in the reports. -Rick

methylene blue: NIH article
 

Here is a recent NIH article on MB

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765788/

conclusion

This study provides the first demonstration of the anatomical, metabolic and behavioral neuroprotective effects of methylene blue in the striatum in vivo. Co-administration of MB provided effective protection against striatal structural damage and oxidative stress. MB also improved brain metabolic activity and some features of behavioral impairment elicited by infusion of the mitochondrial toxin Rot in the striatum. Further testing of MB is indicated to help determine its potential value as an effective neuroprotective intervention in clinical conditions associated with oxidative damage and energetic failure.