Normast for Chronic Pain. Anyone try it?
 

In the thread below last year someone posted about a supplement called Normast and how it helps various types of nerve pain.


http://neurotalk.psychcentral.com/sh...hlight=normast



It's still only sold oversea's but wondering if anyone has tried it? It looks legit.

http://www.painkillernormast.com/slide-view/research/

Lots of things look Legit. I looked at this in the past, and it
does not look like it is a serious risk. I believe you have to
send to Italy for it. But that have changed.

I have not seen a review on it either. One would think by now if it were a great thing, it would be more available and more talk about it.

There is a new website on this, and it seems the supplier has moved to Netherlands. It does seem too good to be true, however.

http://www.youtube.com/watch?v=EN1t9...eature=related
http://www.youtube.com/watch?v=jFle7...7&feature=plcp

A few minutes ago. I am thinking about trying it.

Also, a study with this combined with Lyrica helped as well.
http://www.youtube.com/watch?v=c5bGCiruQUM

pay close attention after 14:35. Sounds like this has very high success rate.

http://www.youtube.com/watch?v=SVD3l968Ck4

Try this reference:
http://en.wikipedia.org/wiki/Palmitoylethanolamide

It appears that PEA works on cannabinoid systems (marijuana).

Not much in the way of human trials however, and they were small, and required at least 2 months to see effects.

I could not find anything "alarming" about this substance but I remain guarded that it will actually work. Also on their main website was a fellow who had his confiscated by customs. Then the supplier claims..."all fixed".

I am slowly watching this video...the 3rd link in your post.
The presenter is going very fast... but I just saw him say...
PEA is effective in MULTIMODAL use...meaning used with other treatments. Also I am getting the feeling you will need to take it all the time. That its effects will wear off if you discontinue. But I am still watching...I have on pause now to have some breakfast.

If you believe the YouTubes (and there are many on the net with "believeable" things), nothing is stopping you from trying it.
I try things after long consideration myself, and some have been very successful for me. You could be our first guinea pig with Normast!

Also the study in this video and the topic involved sciatic pain. Keep that in mind. Allodynia may be different.

There are some new postings on the net regarding low dose Benadryl (5mg every 4-6 hrs) as suppressing inflammation due to MS (improving functions). It is thought that it reduces inflammation of mitochondria, at this time.
It is about 1/2 teaspoonful of children's liquid Benadryl. Since it seems to work for MS lesions, it may help with other nerve inflammatory problems.
That video showed some histamine receptors in the glial as possibly problematic.

Treatments aimed at targeting the Glia is what Nancy Sajben MD believes is the future.

http://painsandiego.com/2012/01/29/g...eatment-fails/



I also found a powerpoint on it.

http://prezi.com/zwefx9bmle96/palmit...of-of-concept/

Yes, the glia are also involved with opiate tolerance, and the formation of new pain receptors.

I am going to try the low dose Benadryl myself. I use it at bedtime in regular doses, and it seems to help my feet when they are acting up.

There ARE histamine receptors in the brain. So it is worth a try.
5mg is below the threshold for side effects. Apparently there are none at this dose.

Mast cells are allergic histamine release cells. Keep that in mind, also.
http://en.wikipedia.org/wiki/Mast_cell

So your saying this could possibly cause tolerance and more pain?

What I am saying is that mast cells seem connected to glial functions as well. So that it appears that glial cells do MANY things. Mast cells are signalling cells. So blocking them blocks the inflammatory signals as well.

The low dose Benadryl connection has to do with swelling/damaged mitochondria. Mostly online the comments revolve around MS.
But the increased perception of benefit for the MSers is neuropathic in type. So it might help us too.

So far I think the Normast data, is speculative still. The new work done in late 2011 is more recent than when I searched it last, when it was still sold out of Italy. Just keep in mind that it doesn't work for everyone. But if you are game, give it a try and keep us in the loop, etc.

I just emailed my pain managment doctor to get his approval. Its going to cost about $220 for the 2 month supply of meds. That includes shipping and the conversion from Euro to dollar.

MY PM Dr. is a good one and open minded. Let's see what he says. Trying this is a better alternative to raising my Namenda from 20mg to 40mg.