Wearing Off & Dyskinesia
 

Hi there:
I am writing this post on behave of my father who is a Parkinson patient since 1998. He is facing problem due to wearing off and Dyskinesia. The effect of sinemet is getting shorther and shorter and If he takes sinemet early, he faces dyskinesia. Is there anyone who is facing the same problem and please tell me how you can manage it? My father was saying that there is a complex solution available for this problem. Do anyone please share his/her experience how to manage it? I will be thankful to you.

Regards
Khalid

Good question ...
 

I hope you get some good answers.

Neil.

I'm not a doctor and I don't (yet) have dyskinesia, but a Medscape article looks interesting.

Medscape give many suggestions including:

"decreased L-Dopa doses, administered more frequently, may be helpful in reducing peak-dose dyskinesia... However, this is only a temporary approach and has the potential risk of worsening patients mobility"

State-of-the-art Pharmacological Management of Dyskinesias
http://www.medscape.com/viewarticle/718544_2

John

plenty of good resources
 

many inexpensive books on pd at amazon.com and elsewhere.
"THE PARKINSON'S DISEASE TREATMENT BOOK" by J.ERIC ASHLOG is good.
i'd read the sections covering your father's pd stage which most parkinson's patients eventually face. it will definitely help you discuss his options with a neurologist.

Deep Brain Stimulation - DBS - was developed to help treat the wearing off / dyskinesia problem with advanced parkinson's when all drug options were no longer effective enough.

I believe ...
 

He might be better flattening out the ldopa spike thru a constant release drug like stalevo.

Neil.

Thank you very much for all of your who replied to my thread.