Lyrica vs Gabapentine
 

I tried Lyrica for a few weeks several years ago and it didn't go well.

So I tried gabapentin.
With the gabapentin, every time I increased the dosage, the pain subsided for a week or 2, but always came back 100%. I was up to 3200mg/day and after a several months, it was not effective at all and the side effects became unbearable. So I stopped that.

Right now I am to the point that I can't live with this pain and am thinking of trying Lyrica again, since going back to gabapentin is not an option.

My question:
For those who are successfully using Lyrica, can you describe how much it helps. That is, does it just take the edge off, or does it really help with pain significantly? How significantly? What dosage is the sweet point for you?

Thanks

Hi there,

I tried Gabapentin to start with, it was no use at all, gave me some really funny sensations on my skin.

My neurologist suggested i try Lyrica, which i started on Boxing day. I started on a very low dose of 25mg am and 25mg pm. i am now on 50mg am and 5opm. I am finding i am getting very good relief from it. It is either that or i am feeling better and things are getting better. I haven't missed a dose so not sure if i am actually getting better. i have a much better quality of life now and feeling alot better in myself too. Hope this is helpful and hope you too can get some better relief.:)

Yeah, that sounds about right. My experience with gabapentin is that all it really does is make you tired and weak. Thats why it is sometimes prescribed for other uses as well. Studies have shown Gabapentin is really no stronger after 1600mgs. It loses its efficacy. Gabapentin actually only helps 30% of the people who take it. Its a desperate option from doctors, like most medications are for this awful sickness.

I found Lyrica to be awful, total zombie time even at its lowest dose. What i found particularly annoying was that it slowed my reaction time and i didn't feel safe driving on it/ I also simply did not feel like me, i felt like someone else completely. If you're the kind of person who can stay home all day and vegg out it may be an option. i just dont see how you can function as a normal human on it.

Patrick,
I had exactly the same experience you had with Lyrica, but I'm getting desperate. Yes, I was a zombie. No, I can't just vegg out. And yes, I didn't feel it was not safe for me to drive.

Guess there aren't any other options that would allow a person to live any type of "normal" life. Seems like anything that helps pain puts us in a zombie state, which is just awful.

Thanks for the input.

Have you looked into the antidepressant medications? Many people get a significant reduction in pain from various antidepressant medications.

Of course, just like anything there are side effects which vary from person to person. But, it doesn't seem like they cause the "zombie" feeling as frequently as lyrica does.

I've been taking gabapentin 1800 mg/day for about 9 months. It's been working OK, but I may need to try something else soon. (Seems like its starting to wear off before the next dose is due - and I don't really want to increase dosage because I feel any more would make it somewhat risky to drive long distances.)

I have found that the supplements can be helpful at at least reducing the pain level. Most notably R-Lipoic, B-12 and ALCAR. R-Lipoic must be taken in a fasting state. I personally take 300mgs of R-Lipoic a day and have pretty good response. There are also clinical trials that show it may actually help heal the nerves. I also have found that you just have to simply avoid white carbs, sugar and pretty much anything that spikes blood sugar because it will stimulate the nerves and you don't want that. i have lost 50 pounds as a result in the past 8 months. I actually have gotten a bit too thin for my liking but I have had all blood work done and doctors are saying stay with whatever i am doing. I still take a 300mg gabapentin at night becuase by 9 or 10 PM the burning starts to kick in. I would prefer to not be taking it though, hope i can get there at some point.

I read these forums daily, but rarely post. I really appreciate the feedback. As I said, I'm getting desperate.

Regretfully, I tried antidepressants for about a year. They helped (very) slightly (in that I slept better), but on the other hand I just sat around all day and didn't care about doing anything all at. So I stopped them.

Several years ago, I did the no sugar, supplements, lost 30 lbs, etc. and after 9 months, I felt worse, so I stopped that too. None of my labs showed any improvement either.

I have resigned myself to the fact that I'll never be able to do anything again. What ever I have to do to get through the day I do, even if it means staying in bed for several days in a row.
Just chimed in here in hopes of something new for the pain.

(Wish people would try to understand how this disease works, instead of my having to explain myself at every turn.)

Thanks

I definitely understand where you're coming from. But, there is the old adage with supplement therapy - it took years to destroy your nerves, it will take at least that much time to help repair them. The medicines arent gonna cure it, at least there are some promising clinical studies that show success from the supplement therapy. In some cases, people arent taking high enough dosages of supplements but its an uncomfortable thing to kind of make yourself a human lab rat. there are a few folks in this forum who have told stories over recovery over time and I find that helpful. Doctors will either tell you nerves cant regrow or that there is no cure. I refuse to accept that. the body wants to heal.

I get very frustrated watching my entire family eat stuff like doritos, ice cream, pizza, cookies, etc. While I have my 4th 2-carb salad in 2 days. But, Something about the brutality of the the vibratory sensation of SFN that has me unwilling to take a chance. Every now and then i actually steal a potato chip chew it in my mouth and spit it out without swallowing. i actually can notice my neuro symptoms get instantly triggered from swallowing as little as 2 or 3 potato chips or a small piece of candy. Tested for diabetes and glucose intolerance and numbers are perfect.But, nerves do not like blood sugar spikes. This is true for all versions of Neuropathy, Fibromyalgia, MS, etc.

I was under the impression that Gabapentin is an antidepressant?

It was actually first developed--
 

--as an anti-seizure medication (as was Lyrica)--an anti-epileptic, if you will.

Both are designed to upregulate inhibitory neural transmitter levels in order to stop damaging overpropogation of neural impulses, such as happens in seizures, and in situations in which nerves are damaged and can't stop firing, which is why they are used for neuropathy so often.

But certainly, both these drugs act with different mechanisms than the standard anti-depressants, which are designed to keep more of the feel good neurotransmitters at the neural synapses (and/or inhibit the enzymes that break those neurotransmitters down).