Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot
 

Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study

http://www.ncbi.nlm.nih.gov/pubmed/2...?dopt=Abstract

More on Thiamine
 

This is a no-brainer. Hope someone with PD insists their doctor try this.
The FDA can't possibly object.

http://www.neurores.org/index.php/ne...rticle/155/156

Note that our PD patients improved dramatically in a short time with thiamine supplements. Days after thiamine treatment, they smiled and walked normally with longer steps, and increased arm swings, and no tremors or sialorrhea was reported. Three patients did not receive carbidopa plus levodopa and cessation of those medications did not effect on their movements. The most effective treatment for PD is levodopa in combination with a peripheral decarboxylase inhibitor (carbidopa or benserazide). In a murine model, dopamine has been reported to suppress mouse-killing aggression (muricide) induced by a thiamine-deficient (TD) diet [8]. This suppressive effect can be potentiated with carbidopa [9]. Patients with PD who have undergone levodopa therapy have significantly higher cerebrospinal fluid (CSF) levels of thiamine diphosphate (TDP) and total thiamine than those patients who were not treated with this drug [1]. Moreover, thiamine deficiency can decrease the concentration of dopamine in the striatum, whereas animals fed on a diet that contained 5% ethanol exhibit increased dopamine turnover [10]. In an experimental TD study, a region-specific vesicular dysfunction (i.e., decreased levels of dopaminergic metabolites) was observed [11]. Dopamine release ii induced by intrastriatal administration of TPP or TDP (up to 1400% and 249% of the basal levels, respectively), reduced dopamine levels in the striatum may occur in cases of thiamine deficiency [12].

Dose?
 

Would have been helpful if they mentioned the dose, and the form of thiamine given via the intramuscular injectionons. Hard to get a doc to try this if you don't know the basic protocol to follow.

calling Sim00
 

Agree that the dosage information would be helpful, lurking. My mom is going to her MDS tomorrow and is going to ask about this.

Based on the last names of the study authors, I think this trail may have been in Italy. If I recall correctly, Sim00 was receiving intramuscular thiamine injections in Italy. Sim00, could you kindly send along an update when you have a chance. When you wrote on July 15, you seemed to be doing well. I hope your improvements have continued.

Would also be good to see a control trial on this at some point. I wonder if one is in the works.

Thanks, all!

:):)

Hi all, I think that intramuscular injections of Thiamine are very helpfull, you can see a good result especially when you are starting this therapy. I feel good in general, but I don't have the countercheck if I don't use Thiamine.
However the dosage is 100 mg twice a week, intramuscular injections. In Italy I use Thiamine called "Benerva".
See also this link: http://www.ultimaedizione.eu/parkinson-eng/
with the last interview with Dr. Costantini, and videos of patients treated, first and after.
Regarding a clinical trial, in the link is mentioned Dr. Fancellu in Genova - Italy.

100 mg twice daily injections
 

In reading the accompanied studies it looks like the dosage given was 100 mg twice a day rather than weekly?
Perhaps you are now on a maintenance protocol?


Hi all, I think that intramuscular injections of Thiamine are very helpfull, you can see a good result especially when you are starting this therapy. I feel good in general, but I don't have the countercheck if I don't use Thiamine.
However the dosage is 100 mg twice a week, intramuscular injections. In Italy I use Thiamine called "Benerva".
See also this link: http://www.ultimaedizione.eu/parkinson-eng/
with the last interview with Dr. Costantini, and videos of patients treated, first and after.
Regarding a clinical trial, in the link is mentioned Dr. Fancellu in Genova - Italy.[/QUOTE]

[/QUOTE]


Hi,
Your observation is entirely correct, but they are two different studies. In any case, I think we can also try to make it twice a day, there should be no side effects (consult your doctor first. I'm not a doctor), for a few days and evaluate their effectiveness. Remember, however, that thiamine to be more effective should not be taken by mouth, but for IM injections.

Before After video's of thiamine treatment
 

The site that SIM00 referred to also has video's of the PD patients.
They are in Italian with English subscript. The younger patients patients seem much improved.
http://www.ultimaedizione.eu/videos-...nts-treatment/

Wonder if you can do this at home? Intramuscular injection. Thiamine sold in vials and insulin injectors, buy online?

http://www.ultimaedizione.eu/parkinson-eng/

Hi,
sure you can do it at home. In my case, my wife, becomes a nurse for a few minutes.
I buy it in pharmacy, and requires a prescription.
Remember not to expose it to sunlight, because more is exposed becomes more ineffective.
I do not use syringes for insulin, but common 2.5ml syringes.
:winky:

I had an appointment with my Neuro today and provided him with the info on this thread about thiamine. He was very receptive and he agreed to try it. He told me he uses thiamine as a treatment for some of his patients with dementia. I will be given thiamine early next week. I am looking forward to trying it. Will keep folks posted.