Leaky gut and autoimmune diseases
 

This article is interesting, and you can follow the references for further fascinating reading:

http://www.ncbi.nlm.nih.gov/m/pubmed/22109896/#fft.

I have a PDF, but haven't been able to find it online in full. If someone comes across it, please post it in case anyone is interested. I'll see if I can track it down tomorrow.

Edit/Addition: Here we go, a PDF: https://www.google.ca/url?sa=t&rct=j..._BVU0A&cad=rja

Dr. Fasano--
 

--is one of the world's leading experts on celiac and other gut based autoimmunities.

We've had a lot of discussion on the gut-autoimmune connection here at Neurotalk in the past, particularly on the celiac/gluten sensitivity forum. For a very extensive database on all this, including the mediating effects of zonulin, "tight-junction dysfunction", genetic differences in reaction to antigens, etc., I do recommend perusing The Gluten File, which can be accessed through that forum:

http://neurotalk.psychcentral.com/thread1872.html

Glenn, thank you for this useful link. As I read more and more last night, into the night, and much of today, I learned that he is quite the star, an excellent physician and researcher. I've read a number of his papers and studies now, and some others. I had no idea. What fascinating and important work!

People might find this useful too: http://chriskresser.com/pioneering-r...ity-leaky-gut/.

I will look on this forum for that, thanks. I'll also explore the link you sent. There seems to be a lot there. It seems that he's confirming that gut based autoimmunity is more like gut originating autoimmunity, given his work on other, ostensibly non-gut autimmunities, say MS and the others he mentions. It seems that leaky gut is the door through which many problems and autoimmunities develop. And then there's the drug that might be out in 2018. I wonder. I wish I had been test for CD back when I was still eating gluten, but it's too late now. I can see if I can get the genetic testing done, but that will just rule it out, not confirm a diagnosis.

I suppose all I can do now is work on healing my gut and see what happens. Perhaps I will stay off gluten for the rest of my life. A big sacrifice, if I have no issue with it, but that's life.

Thanks for sharing these links. I agree this probably is a factor with some neuropathies. My gut was the first thing that went wrong, now I have 2 problems that happened at the same time I think are autoimmune, one is the neuropathy type thing.

I did try the paleo diet for a month with no results. I think the problem is once this process has happened it is v hard to reverse. The thing to do is nip it in the bud when you first start getting gut problems. That is hard to do seeing as doctors don't understand these things and what to do to prevent these problems occurring if you go to them.

You're welcome. I knew about this view, or the general theory, but hadn't looked into all the research on it. I've now read through about 2 dozen articles since last night and I find it all extremely fascinating.

Diets often taken longer to correct damage and will need longer trials, I find, and this is suggested anecdotally and by studies. On the other hand, if you see no improvement at all in 1 month, then I don't know, since there should have been some improvement, even if very modest. But it also depends on the quality of what you were eating of course. I also started supplementing at the same time and within a month I saw good improvement, but it took a few months for me to see radical improvement, and vitamin D made a huge difference too, same with NAC.

Well, studies and anecdotal reports show that it can take years to heal severely damaged intestinal walls, but that it can be done. It needs to be done properly though. Certainly in some cases it may not be reversible, but modest gains can still make a big difference for those suffering.

My gut is as bad as it gets and I've had good gains in the last few months. I let it go for years and years, and ignored all the signs unfortunately. Then the neuropathy hit - though I ignored those symptoms for months, maybe years too. I hope for more progress in the months to come. So far so good.