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Deplin
this is the drug i will be going on
i have much hope i am thrilled to learn what i just have love me |
Eva, I take otc methylfolate and have been for several years.
http://www.foxnews.com/health/2013/0...epression.html Good luck with it. Most days I take 800mcg of methylfolate and it's in my homocysteine formula I take to lower homocysteine levels. It's the best form of folic acid. |
Eva, just talking to my friend who put me on to the Methylfolate issue a couple yrs ago, she knows a lot about this folate and says make sure your B12 is sufficient. The extra folate intake can mask B12.
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thank you thank you just learned i have a MTHFR MUTATION a direct cause of many aliments i suffer thyroglossal duct cyst for one depression diverticulitis and on it could be a big changer thank you love me |
Eva, it is good to read that you have learned that you have a MTHFR mutation - those mutations can have many adverse effects
As far as I know their effects can be overcome by taking appropriate supplements, I think that mrsD is the resident NeuroTalk expert on this - maybe check out her posts or send her a PM - I am sure that she will be able to give you good advice about how to use supplements. All the best. |
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DEPLIN has been shipped
I have had a heck of a roller coaster ride
Getting this very important vitamin It was explained to me by the company nurse I do not have to take any additional supplements That it SHOULD be all I need to take I was wondering It is to cover so many areas I am anxious to start it Not much feedback Will look to MrsD for any advise I still yet to get it into my system Will keep posting Should anyone else be recommended to try DEPLIN Me |
Eva, Deplin is a trade-name for L-methylfolate.
What that means is that it will increase the levels of L-methylfolate in your body, which are probably low because of your MTHFR mutation. I am sure that mrsD will be able to offer you more detailed advice than I can but in the meantime this general information might help you; http://www.drugs.com/cdi/deplin.html. As far as I can see Deplin has an excellent reputation and I really hope that it works for you. |
Am I misunderstood
Dear informative friend
I have no doctor on my very important train that I'm driving I yet to find a fairly decent general practitioner to get on board and take me seriously As we speak I will be seeing my OBGYN for my annual check up never in my history knowing this body well since a young girl and have been on spot about everything This be the truth I just fired my shrink having been asked by the insurance company for my profile If I'm paying for my bloody insurance As it is deducted from my ssd income And in addition copayment and coinsurance deductible I am paying for services I EXPECT TO GET how can that happen WHEN NONE OF MY VERY IMPORTANT DOCTORS ARE NOT PAYING ATTENTION AND IM TIRED OF EDUCATING THEM what I am saying Not my shrink who dispenses meds (7 yrs) Not my pain specialist (8yrs) Maybe my oncologist asked me to bring in the information on the subject (on board the last four years after double mastectomy anniversary 1-9-12) My OBGYN hasn't a clue until I see him today annual pap I missed last years as he was busy delivering babies the office called to cancel my appointment that I would get a call for rescheduling NEVER HAPPENED this year I must go I except for last year never missed my annual Here is what I mean Never say never I am going to pray he sees the connection Lets see who else I have had check ups on my skin dermatologist I had my colonoscopy (clear) that in itself is awesome news as this mutation and I positive of one of the two variants with a high homozygous Foot dr, dentist not as often with my neck shoulders and back yes the pain is that great As a matter of fact I live on the 19th floor Getting on the elevator is excruciating Nevertheless This is how I take care of me and my children I like to practice PREVENTATIVE HEALTH CARE however I am finding out the doctors really aren't paying attention For example My ex ENT I needed to see for clearance for second surgery was told upon looking at me not my report or the reason I was sent there expressed he did not believe I had a thyroglossal duct cyst Now I have reached Being so long winded for oblivious reasons Oh just remembered My reconstructive surgery (BOTCHED LEFT IMPLANT HAS WHAT IS CALLED A "DOUBLE BUBBLE" was lied to for two years until my oncologist requested me to go back to him Turns out they are racquetball partners Go figure What are the chances with my luck So Not one doctor seen the red flag And that is I have tested positive for the MTHFR MUTATION and now the connection that the ONLY WAY one acquires a cyst such as mine and the "neural tube defects" it will cause as in my case all is true because of the findings of this very sick degenerative inflamed body Not any of the above doctors get Nor do they seem to care SO I feel lost and alone Why would I be not be told As I asked the right questions because of my homework the conflict If it is the SAME meaning DEPLIN just another name for L-methylofolate am I being lied to I have no understanding and the array of vitamins I was asking of Still no clear understanding is and could be quite expensive I am on a very tight fixed income It S.U.C.K.S I not only want to limit the amount of things I put in my mouth Is enough already So the thought I am being misinformed And that taking 15mg DEPLIN in tablet form AGAIN SHOULD (this is gray for me I admit) Yet this is what was explained to me ONE tablet I am so confused at this point I don't know if I'm coming or going Hope I'm better understood And look for any support here on NT THANKS Me |
In short.... The MTHFR mutation affects B12 as well as folate.
If you are not methylating B12 then you do not have active working B12. Taking high dose (and you are taking mega high dose) methylfolate and NO B12 to balance it, will lead to neurological damage. This is why Deplin is an RX item to prevent people from misusing it. https://umm.edu/health/medical/altme...-b12-cobalamin do you know your B12 level? Many doctors still do not know that 400pg/ml is the new acceptable low for B12. Did you check the links I gave you? Doing your own supplementing of Bcomplex, methylfolate and methylB12 can cost only about $40 for 3 months supply...and you are paying more than that for one month? I would suggest you supplement AT LEAST the methylB12 yourself. It must be taken on an empty stomach for best absorption. It will only cost you pennies a day. |
Well thank you MrsD
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NO doctor on my train are interested And the massive information only confusing me to NO END I WILL CALL THE COMPANY AND INFORM THEM WHAT YOU ARE SUGGESTING NO DOCTOR IS EVEN INTERESTED are you kidding me to come here for help I look to I would much rather take what is necessary at the least cost It may be easy for some to understand Understand this When my pictures of my hands and feet were bruised as pictures tell a better story No story I was then tested for worries of clotting I found this information among the test And NO DOCTOR RED FLAGGED IT Or connected the dots How about this Can I ask you this Now that I will be taking DEPLIN You suggest I take B12 How much of it Calling the company now I am not in a good place withdrawal is kicking my butt Sad Just so damn *** sad Thank you very much Love Me |
thank you
Spoke with company RX Chad
He tells me not correct And that he gets many calls with the same question I will need to get a nutritionist on board I have yet to look into that I will begin DEPLIN with a regular multivitamin in addition a proper diet of which we always practice He explained as I read exactly what you suggested And he said neurological things anxiety depression even as far as seizures are these the neurological problems you speak of as I am aware of them I always knew I was sicker than sick when having cervical neck surgeries As all that was happening NO DOCTOR WAS LISTENING TO ME TWO YEARS LATER I FOUND MY BREAST CANCER I FOUND "IT" No one was LISTENING I will continue to post Product should arrive in three days I should feel affects in two weeks This cookie has always been in tune with this body and what going on When I was having screwed up cervical neck damage done to me by a doctor Who then could not look into my eyes when I acquired horners syndrome My left pupil fixed A direct result from hematoma botched job This I know The back of my neck feeling foreign to me all changed to the touch Never have I ever felt so helpless Maybe you can understand my fears and concerns Me |
Well, I see my job as one to protect people here.
I've now discharged my knowledge to you twice, so you are on your own. Patients with the MTHFR mutation have effects on both folate and B12. That is not just my "opinion" but it is all over the net by experts. We have a B12 thread in the stickies on PN forum. B12 is over the counter so you can take it yourself. You can start at 1000mcg (1mg) daily on an empty stomach. It is sad that you are not receiving better care and treatment. http://www.drugs.com/cdi/deplin.html Deplin is not a drug...it is classed as a medical food. From what I have seen online over the years, it doesn't work well for some, and can have some unpleasant side effects. It is a very high dose and some people cannot handle that. |
Again I say thank you
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I do not trust anyone Though I will be able to give important follow up as how it is helping me Wouldn't it be WONDERFUL if it helps And that is the bottom line As my shrink said asking him to help Intact was "tedious" Let me not be a burden to anybody I have done all I can for now To many things going on at once I get what you are getting across about the Company and MONEY MONEY MONEY THAT IS WHAT THIS COUNRTY HAS REDUCED ITSEF TO shame on the doctors pharmaceuticals And as I get older the worst off are "WE THE PEOPLE" Amen |
Eva, I agree with MrsD and know enough about Methylfolate and have talked to you. If you are taking the 15mg that is a very high dose. I have a friend who takes close to 2mg and I'm right there with her, I take a little less, but we both make sure our B12 is sufficient. We buy both otc. Can only wish you the best.
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That's just awesome
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Let me ask you something Do you know anything about this body Did you even do any homework on a thyroglossal duct cyst Something this body had been suffering with An active one I came to NT FAILED CERVICAL SUGERY and have been around I find it amazing that the school would put the kinds of food for our youngsters to start life off with a unhealthy bang Always sent my children to school with a balanced meal And would put an extra serving for another students in the class They would eat Corissa's lunch The help I am looking for is something many WILL NOT UNDERSTAND However I expect common knowledge to be exactly that I had many different variants to look at This mutation is just another thing to put on the list of problems As my cyst is active And I have been to three reputable ENT SPECIALESTS WHEN I HAD PRIVATE INSURANCE by the way A person in this country could DIE before they could get health insurance This a disgrace I now in a difficult place Yesterday at my OBGYN He had the decency to tell me Eva I have limited knowledge of genetics Since seeing three ENT's THESE ARE THE THREE RESPONSES 1st one told me it does not LOOK like you have one 2nd one told me it is something I need to keep an eye on 3rd one asked why did the neurosurgeon not have it removed when he entered my neck anteriorly this ENT NEEDED TO CLEAR ME FOR SECOND SURGERY do you even know what it's function or purpose is of how I acquired it The third ENT said It should have been removed Did you know that goiter is prevelent on my mothers side My mother and all her siblings three of four has them Members of my lineage have died as a result of complications To much iodine when doing the surgeries so the story is via my mother After my first ACDF 5/6-6/7 and failed to fuse I had no choice in the matter My surgeon asked me Why would I return to him to fix the job My response was this Dr. Peterson why would I go to another person Isn't what you did "YOUR ART WORK" "ONLY YOU KNOW WHAT YOU DID" WITH THAT NOT A WORD AS HE DRAINED THE HEMATOMA THAT GREW OVER NIGHT" I trust nobody Including the OTC meds Since my failed second surgery I was reduced to wearing a soft collar all of the time Until about a year now My cyst has become bothersome Why do I bring this up HORMONES another reasons doctors are misdiagnosing Another biggie as diet and proper nutrients are to ones body I will continue to post And let others know how things are going May all who look for help Do your homework Thoroughly I do not believe everything I read or hear on television How about this There is a neurologist who is cunducting a study His name DR. KEVIN TRACEY OF NEUROLOGY based out of NYC my back yard "Believes" and has proven that all things such as inflammation be the VERY FIRST SIGN of something gone wrong He believes and so do I doing extensive research LIKE I SAID WITH THIS BODY EVERYTHING "IS" interconnected He has a site if you type in his name and state You will find a site called "CAN THE NERVOUS SYSTEM BE REBOOTED" A LARGE pharmaceutical COMPANY WANTED IN AND GAVE HIM A HUGE SOME OF MONEY FOR HIS REASEARCH THAT SPOKE "VOLUMES TO ME" THERE IS MONEY TO BE MADE AND THEY WANT IN BECAUSE WHAT THIS DOCTOR PROPOSES NO MEDICINES ESPECIALLY FOR THOSE LIKE MYSELF allergic reactions Deadly side affects Not any different then the DEPLIN Always everything with caution and knowledge HOMEwork this I have done As it is what is left of this dying body It is rotting before my doctors And "they don't give a turd" INSTEAD IT IS WHERE'S THE MONEY A sad country it has become I came to this country at five My father had some idea that the western world The only world I know Is way ahead of itself Me |
my child Eva's mom
TESTED POSITIVE
FOR THE MUTATION just spoke with her her doctor will be doing more tests AS IT EXPLAINED not only is more than 50% of the population is affected it would be great to get more info on the mutation on the forum |
There is already much information on the NT forums.
Just search MTHFR ... lots of posts on the PN forum. |
my child Eva's mom
TESTED POSITIVE
FOR THE MUTATION just spoke with her her doctor will be doing more tests AS IT EXPLAINED more than 50% of the population is affected it would be great to get more info on the mutation on the forum just some FYI happy knowledge i was put on a high dose as i am at the extreme side to the mutation i Should benefit from this http://www.balancingbrainchemistry.c...epression.html |
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should help this is new to me and i went through the site not broad enough info as there are many interconnecting ingredients and the lack of and so on I arrived JUST TOOK MY FIRST TABLET with my multivitamin 50 plus will continue to post |
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thank you MrsD ME |
first time in i don't know...
how long it's been i have slept through the night
it was four in the morning to void liquids it was that gut feeling i had anticipated waiting for it as i returned to bed and wondered when i would be visited by doom and with that i fell back to sleep 7:01 A.M. i awoke this to me is greatest thing ever for this body has a chance to feel just a bit better i'm going to share it me |
Good news Eva, hope it continues for you. I can't imagine how horrible it is not to sleep. I've had some bad nights in my life, but not anymore.
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Eva, that is good to read :).
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Thanks
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Thank you May it continue As I am very hopeful All the best Me |
he wouldn't stop calling
so i answered
and we both had things to say back and forth though i am the one who has been suffering and after reminding him of his comments he agreed he should not have had the reaction he gave me will call me in a few weeks to see how i am doing we shall see we shall see i have lost all hope and faith with him makes me very sad me |
An even longer night
I just want to keep an update and log
I slept like a baby last night I did not feel my pain That's how deep of a sleep I was in Dreaming is the next thing I hope to do I cannot remember when the last time it was I had a dream and it was remembered To honestly tell you I had an awesome night sleep Went to bed at 11:20 Fell right to sleep Woke around 5:15ish in the morning to void Went back to bed awaiting a visit from depression I PRAY not there will be a hiatus to be expected AND I CAN FEEL THE CHANGES IN MIND AND BODY I tell no LIE I have nothing to gain AND REMEMBER this is my experience My mechanical botched job And my other problems are still there Only now I do not have my visitor of doom come to visit And bring me down So for many who are not doing well with their ANTIDEPRESSANTS as none of mine worked for the better Infact my antidepressants put me in an even worse state are recommended to take a product that acts as my mega vitamin is doing for me All I suggest For those who suffer in this area you may want to look into it Is there a reason the antidepressants aren't working If you are a woman having difficulty becoming pregnant such as ectopic mis carring A MTHFR MUTATION WITH CERTAIN VARIANTS COULD BE A CAUSE and I believe if more than 50% of the population has it And all else has failed Ask to have the test done It can even be done with a swab of your mouth Don't know if I will get a chance to feel 100% because I am withdrawing from my benzo med Xanax 2-1mg twice a day I am down to 1 and .05 a day And the withdrawal is kicking my butt Overall it was recognized by several persons I was in better spirits and they do not know what is going on So I would say this is a SUCCESSFUL STORY Especially since I have never abused my meds when my life changed forever And most IMPORTANTLY I did not pick up a DRINK I feel SO much better about this And begged my oncologist to do his read As I gave him all the information I found on MTHFR mutation high homocysteine And what that could mean and definitely a cause of some symptoms directly from this mutation Hope he reads it He was not that knowledgeable of the situation But asked him to please listen I have been a fighter all my life The sad thing is MOST times it's with persons who lax at their job and the recipients in any need can just sit if its hard to walk Use the phone I am darn proud of myself Not full of myself alone I didn't give up So message is DO NOT GIVE UP YOU JUST HAVE TO HOLD ON AND PUSH THROUGH I worked real hard for most my life Then my life changed forever after that with the rest of my spinal problems and the things that followed what is referred to as the domino effect I wish and hope this helpful info Me |
Eva, have you ever had homocysteine levels checked? You know I have as MD did this about 3 yrs ago and I guess with the aging body. I need to get my levels checked later this year as I continue with my formula of MFolate, B vits and TMG.
http://familydoctor.org/familydoctor...d-vessels.html Good to hear you are feeling better and sleeping so good. I have NOT followed your journey with meds etc. But that's OK, sounds like you are on a much better path. Enjoy hearing how you are doing....again watch the B's and potassium levels too. So much works together. |
Thinking about this more and more, I'm beginning to think about the importance of Folate and SO MANY (MOST) do not get adequate folate and I know SO MANY who do not sleep good, sleep pretty poorly actually. Minds are not clear etc etc. Multi Vits have a low amount of folic acid but the Ffolate is the most effective form for assimilation.
I sleep good since my sleep remedy I've posted here and now take Magnesium Chloride tablet before bed to sleep more relaxed and it's working even better for me. |
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one thing comes to mind why if more then the 50% of the population has this why would it not be on a standard blood panel this mutation can be a biggie for some good to hear you get good sleep in it is so important for the body thanks me |
My friend who is challenged with CFS/ME is on phoenix rising group and she says a whole section is devoted to the MFolate issue and a large number of people have the mutation. And she goes on to say, most doctors don't know about this MTHFR mutation, and hand out anti depressants... maddening..
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my shrink would just give me antidepressant after another now i understand trial and error and no success is because it was not being processed hindered by the mutation awesome to know it is out there now my shrink is sending me samples think his consciousness set in and seen how i was failed by him he said he would call in a month to see how i doing after a month on it told him that would be fine |
Some hope
Dear friends
I cannot begin to tell all the difference The significance The positive improvements that are occurring While the Xanax Still kicking my butt This only a .05mg decrease in morning dose Kicking it I tell you And it is the Xanax for certain It helps when one takes a look at their body And LISTEN TO IT greatful I am to have pushed through And did my homework This only my two cents |
feeling...
awesome
awesome awesome will keep posting if i'm allowed i accused of being rude because i write in caps i'm very old school had no clue it meant i was shouting I WILL SHOUT OUT THIS I AM FEELING GREAT SLEEPING GREAT AND HAD A MUCH LESS TRAUMATIC EXPERIENCE GOING TO THE BATHROOM I AM FEELING AWESOME do not give up ever keep searching for the source of the problem while doctors turn the other way my experience me |
Eva, it is good to read that you are feeling awesome :).
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Amazed, greatful, hopeful
And this my doctors would just
Sweep under the rug It is absolutely been a uphill battle This a good thing No pain on a mental level Where my mind just is stuck on all the negitive Today again no doom visited me Just the fact I can wake and "not be visited" by this sadness that manifested physically To myself I am true I am feeling so much better since taking some things into my own hands My doctors swept it under the rug Not a concern for helping me find the cause of my hands and feet they cannot deny the pictures The best description I can give as it is invisible to anyone else The inside of my hands Each of my didgets are painful independently The skin tingles with fire If I put lay my hand down it just grows This not the same as the problem that has my doctors scatching their heads The underside on my feet the same only they feel the heat Don't know what it's like to walk on hot coals I wonder This has been the way it's been for many years now Starting in 1999-2000 subtle changes to where things are now This again independent from the inflammation of vein that would eventually pop burst deflate and the to follow a huge bruise They have not a clue Nobody on my train says anything This is heartbreaking Just heartbreaking |
Eva, conventional MD's just don't know how to dig deep and go after what our body needs...we are depleting of so much daily and they just don't know. And truth be known, they really don't care. I believe this more and more the older I get and know of my own health. Happy you are feeling so much better...it can continue.
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Thank you for your well wishes
Things are to to put up with
I do see your faith is on a fence with the ones we put our bodies to take care of If I read you right I have been repeatedly let down and am maimed including my right breast reconstructive I just feel if it is fifty percent and more of the population has this very acute problematic mutation that if picked up possibly could give a good starting chance Only because there is a huge difference A sense of ease even when something is up And sleep did I mention sleep Again thank you for your well wishes You be well Keep searching Me |
feed your brain
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To the pain specialist
3:45 is my appointment
I now need him to make out the script for my Xanax As I fired my shrink after seven years This is not the first time he grossly responded Having to fill out the form for insurance company called a "profile" of was tedious and how doubious The whole thing is Kept calling me after I cancelled ALL my appointments with him After what I went through with the (SNAP PROGRAM) food stamps case closed because I never received my papers to re-certify my case via regular mail a problem in this building It will be interesting to see "bobby" My pain specialist from the very beginning of my spine neck and lower back I will bring him all the info on my success I am not going beg him to do his homework As I have printed out enough for him Loosing my faith Lets not forget He dumped this vitamin Mumbo jumbo stuff for him "Not his speciality" Anyhow It is getting harder and harder to trust the doctors This has been my personal experience The DOCTORS YET TO FIGURE OUT WHAT IS GOING ON WITH THE HANDS AND FEET AND VIENS INFLAMING AND THEN BURST only to leave a huge bruise Already submitted pictures here For persons to view and if anybody else was experiencing what I am "THEY" have no clue But you know as well as I and them Something is terribly wrong I have to fight this fight Alone with my Father at my side Love Me |
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