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-   -   The eyes have it (https://www.neurotalk.org/parkinson-s-disease/234757-eyes.html)

GerryW 04-13-2016 05:33 PM

The eyes have it
 
Dopamine eye drops?

http://www.pharmiweb.com/pressreleas...0#.Vw7HajArKhc

moondaughter 04-14-2016 07:00 AM

thinking abstractly....
 
Quote:

Originally Posted by GerryW (Post 1207896)




I LOVE this!! I wonder at what frequency dopamine would calibrate at..and if there is a corresponding color/light frequency that could then be transmitted...
Thx Gerry!

ashleyk 04-14-2016 08:12 AM

Blue LED "SAD" light box?
 
It would be helpful if we knew what light wavelength was used in these tests. It could be anywhere between UV to infrared? Aren't there other reports showing that exposure to computer displays or fluorescent lights (bluish light) could lead to PD? If the available blue led, sad box light is the wavelength used in this report, it could be very helpful for those with PD. If anyone can find the wavelength they used, it could be useful.

badboy99 04-14-2016 08:48 AM

http://photopharmics.com

https://clinicaltrials.gov/ct2/show/NCT02175472

badboy99 04-14-2016 08:53 AM

Quote:

Originally Posted by ashleyk (Post 1208010)
It would be helpful if we knew what light wavelength was used in these tests. It could be anywhere between UV to infrared? Aren't there other reports showing that exposure to computer displays or fluorescent lights (bluish light) could lead to PD? If the available blue led, sad box light is the wavelength used in this report, it could be very helpful for those with PD. If anyone can find the wavelength they used, it could be useful.

http://photopharmics.com/PDF/phototherapy.pdf

moondaughter 04-15-2016 09:33 AM

frequency specificity
 
Quote:

Originally Posted by ashleyk (Post 1208010)
It would be helpful if we knew what light wavelength was used in these tests. It could be anywhere between UV to infrared? Aren't there other reports showing that exposure to computer displays or fluorescent lights (bluish light) could lead to PD? If the available blue led, sad box light is the wavelength used in this report, it could be very helpful for those with PD. If anyone can find the wavelength they used, it could be useful.

Well... I have learned through studying homeopathic principiles thatt what can cause a problelm in large doses can cure it in very small doses....

My infrared intranasal light is dual frequency (652nm/940nm) and tho effect is subtle I have been delaying my first dose of med in the morning an hour (ever vigilant for opportunities to reduce med)sometimes two hours and feel a deeper sense of calm. I really like it tho it doesn't corroborate the findings in their publication. having said that I also use blue spectrum light in the form of specially formulated sunglasses. perhaps time of day is also at issue here as natural light holds blue frequencies in morning red in afternoon or is it the opposite?

P.S. My earth pulse device that I use for sleeping oscillatees between two frequencies (also) https://earthpulse.net/

moondaughter 04-15-2016 10:21 AM

light and circadian rythyms
 
found an interesting if not useful article that answers my question in previous post: blue frequencies are more naturally (sun sourced) in the mornings- red in afternoon and evenings. I do love firelight !

http://wellnessmama.com/91779/blue-l...mprove-health/

girija 04-15-2016 01:26 PM

sinemet and Glaucoma
 
[QUOTE=GerryW;1207896]Dopamine eye drops?

http://www.pharmiweb.com/pressreleas...0#.Vw7HajArKhc[/QUOT

About 4 years back, I was diagnosed with glaucoma and I suspected it had something to do with PD or the meds. At that time, I found very little information connecting PD and glaucoma. Quite recently, I found out that a connection exists. This warning is a new addition to the list of side effects of L-dopa.

"Patients with chronic wide-angle glaucoma may be treated cautiously with SINEMET provided the intraocular pressure is well-controlled and the patient is monitored carefully for changes in intraocular pressure during therapy"

I am not sure if dopamine would have the same effect as L-dopa.


Girija

moondaughter 04-18-2016 10:42 AM

light with dopamine drops?
 
Quote:

Originally Posted by GerryW (Post 1207896)

"Using the eyes as a treatment pathway, scientists delivered minute amounts of dopamine and other medications to the eye. The treatments resulted in rapid symptom recovery in the animals. Subsequent studies delivering drugs that block dopamine made symptoms worse. Because dopamine in the eye is activated by light, researchers experimented by administering light to the animals’ eyes and found a two-fold improvement over medication.

More: http://www.pharmiweb.com/pressreleas...46C1lQRMYUsing the eyes as a treatment pathway, scientists delivered minute amounts of dopamine and other medications to the eye. The treatments resulted in rapid symptom recovery in the animals. Subsequent studies delivering drugs that block dopamine made symptoms worse. Because dopamine in the eye is activated by light, researchers experimented by administering light to the animals’ eyes and found a two-fold improvement over medication.



yeah....I am wondering whether light alone can be as effective as the combination of dopamine w/light application......

- anyoone have ideas on how to formulate the dopamine eye drops?

moondaughter 04-18-2016 12:08 PM

dopamine eye drop formuation
 
http://www.jneurosci.org/content/32/27/9359.full

"L-DOPA (1 mg/ml) was administered in drinking water containing 0.25% ascorbic acid in applicable experiments. Solutions were prepared fresh daily and shielded from light. Pregnant and nursing dams had ad libitum access to L-DOPA/ascorbate or to ascorbate alone as a vehicle control. After weaning, pups continued to receive L-DOPA and ascorbate for 1.5–2.5 months. Some mice were subsequently withdrawn from L-DOPA for 1 month before testing."


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