Steroid [squalamine] Attacks PD-Related Toxin [a-syn clumps] in Animal Model [worm]
 

"... a clinical trial with squalamine in Parkinson's disease is being planned."

Steroid Originally Discovered in the Dogfish Shark Attacks Parkinson’s-Related Toxin in Animal Model | Georgetown University Medical Center | Georgetown University

Squalamine research paper
 

Besides the press release, the research paper itself is also available.

http://www.pnas.org/content/early/20...86114.full.pdf

(this is an "Open Access" article)

My thanks to Simon Stott for pointing us to this:

"Orally administered ENT-01 [a synthetic squalamine salt] was safe and significantly improved bowel function in PD, suggesting that the ENS is not irreversibly damaged in PD. Minimal systemic absorption suggests that improvements result from local stimulation of the ENS. A double-blind, placebo-controlled study is now ongoing."

Client Request Error

Of particular interest is the part of the claim that says "the ENS [enteric nervous system] is not irreversibly damaged in PD".

John

"ENT-01 for PDD" trial
 

A sentence in the Discussion section caught my eye:

"We observed potential signals of clinical benefit for parkinsonism, cognition, hallucinations, sleep and RBD."

And it seems they are wasting no time. Enterin are also currently running a trial of orally-administered ENT-01 for Parkinson's disease dementia (NCT03938922):

A Study to Evaluate ENT-1 for the Treatment of Parkinson's Disease Dementia - Full Text View - ClinicalTrials.gov

squalamine-supplement
 

You can buy squalamine now and not wait 5 years for clinical trials.



Squalamax - Natural Shark Squalamine Supplement - 65 mg/1 Capsules


Squalamine and Squalamine Supplement

Thanks.

I hope that the trial gives encouraging results.

This is personal for me because an uncle of mine in NZ lived with PD for many years and towards the end had lost a lot of cognitive function.