Gene therapy of the ischemic lower limb
 

Vascul Pharmacol. 2006 May 12; : 16698324
Gene therapy of the ischemic lower limb - Therapeutic angiogenesis.
[My paper] Vladimir Bobek , Oliver Taltynov , Daniela Pinterova , Katarina Kolostova
The limitations of surgical revascularisation and pharmacological treatment in peripheral arterial occlusive disease (PAOD) are well recognized. Therapeutic options for critical leg ischemia are consequently limited to percutaneous transluminal angioplasty (PTA) or surgical revascularisation. Unfortunately, many patients with critical leg ischemia are poor candidates for either procedure. Therapeutic angiogenesis is a novel promising tool to treat these patients. Experimental and clinical and trials of gene transfer for therapeutic angiogenesis have already shown some clinical efficacy. This review is focused on gene transfer techniques in preclinical and clinical therapeutic angiogenesis, angiogenic growth factors, vectors, delivery methods and routes. The results of clinical and experimental studies, safety and side effects of gene therapy, and the perspectives of future research are also discussed.
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http://lib.bioinfo.pl/pmid:16698324

You might be interested in something I've found recently.

The doctors have always said I have excellent capillary refill and circulation in my affected hand but I've always found that working with my hands over my head is very poorly tolerated by my condition and far more likely to lead to pain the following day.

I recently got a tens unit for the first time and have been experimenting (playing) with it. After a session the fingers on the "bad" hand turn quite cold and my blood pressure drops to normal. This can be over a 100 point drop total.

The stimulation just completely buries any low level pain.