Palmitoylethanolamide
 

Hi everyone.....I noticed this January 2017 paper on PUBMED. I found it interesting that Palmitoylethanolamide (PeaPure?) is back on the table in a positive light. I recall this being discussed and I think it is hard to get. Has anyone tried this? I would love to take a "medical food" in order to reduce gabapentin and its impact on memory, thinking and depression!
http://www.ncbi.nlm.nih.gov/pmc/arti...jpr-10-219.pdf

Hi Summerfun

Thanks for posting the link to this interesting review summarizing current treatments for the 3 major types of PN. (Pity autoimmune induced PN wasn't included.)

I notice that Palmitoylethanolamide was indicated as being effective when taken in conjunction with Gabapentin - that it could help to reduce the dose of Gabapentin required and therefore reduce the side effects from Gabapentin. Whether Palmitoylethanolamide on its own reduces PN pain isn't discussed in the article.

I previously researched Palmitoylethanolamide (PeaPure is one brand available) If I remember correctly there was some online information about the varying purity and consistency of what was being sold as Palmitoylethanolamide. It's been extensively used and tested in Europe for several years. Here's some links to some of the info I found on Palmitoylethanolamide

[Full text] Palmitoylethanolamide, a neutraceutical, in nerve compression syndrome | JPR

https://en.wikipedia.org/wiki/Palmitoylethanolamide

Palmitoylethanolamide is found naturally in food including eggs and peanuts.
Hope this is of some use in deciding to whether to include it in your regime - if you do decide to include it maybe try to check as far as possible that the brand you buy is reputable. All the best.

PEA is not water soluble. This makes it very difficult to get into an oral form.

Make sure you have details about what is being done to improve this problem if you decide to try it. Basically it is a rather benign substance, but it presents a huge problem regarding if it is even absorbed. This factor and its enormous cost are the two factors that leave me cold. Basically it is hundreds of dollars a month for nothing.

After all these years of promotion by the European company who is promoting it...and we have one statement that it works in conjunction with lowered doses of gabapentin in mice. There should be more after all this time IMO.

Hi,

I took PEApure for several months when I initially had CRPS symptoms. I personally felt that it was helpful and did reduce nerve irritation. I never did get as severe as some cases and was able to stick to a low dose of gabapentin. Whether this was from the PEApure or something else I can't say, but it certainly didn't make me worse. I felt its long history of being used for neuropathic pain in Germany was a positive thing.

I buy PEApure brand and it is micronized. There is another brand P.E.A. cure, out of the Netherlands that is also micronized to enhance absorbability. They recommend you take it with food.

A month supply of 3 capsules 3x day costs $54-66 depending on who you buy from.

Thanks mrsD. I understand your point and will see if I can find any information on successfully getting it into oral form. I am willing to try it as long as it won't do any harm. If it doesn't work so be it. Like so many of us I feel I just have to do something! I guess that's how some companies make money, unfortunately.

Thank you for sharing your experience. I appreciate it and find it encouraging. If I try it I will let you know how it works for me.

Thanks Summerfun,

I originally misquoted the price because I'd meant to put the 2 month price in not the one month price. Sorry about that

The $50-66 is the price for a month supply. A bit pricey but I've seen worse on specialty supplements and medical foods.