the patch and distribution of meds
 

Does anyone know if the patch distributes carbidopa/levodopa or Mirapex? I was given the impression that it's a slow release for carbidopa/levodopa but now I think it's for the distribution of Mirapex.

Does anyone know?

I'm not sure how many other makers are doing patches. but here is some info -
Neupro Patch - FDA prescribing information, side effects and uses

NEUPRO(R) (rotigotine transdermal system) | 24-Hour Patch

Parkinson’s Disease Medications | Parkinson's Disease Clinic and Research Center

neupro contains a dopamine agonist called rotigotine (so not mirapex or requip and don't try taping pills to your forehead, etc. or snorting them :)

https://www.accessdata.fda.gov/drugs.../021829lbl.pdf

because it is an agonist you only need upto 18mg/day to diffuse thru your skin and that's doable because of the structure of the patch in opening up tiny holes in the skin. if l-dopa could be delivered at a fast enough rate thru the skin a patch would have been developed years ago and i kind of doubt much effort would have gone into developing the incredibly expensive gel delivery systems that have come out recently and for which the drug companies expect to rake in at least $30,000/year for their patented gel formulation of C/L The first FDA approved device is called dupodopa which is available using an external pump which is carried in a lunchbox size carrier. the newer medical device that bypasses the stomach is a small modified insulin pump that requires no surgery like the duopa system, with that system the stomach is completely bypassed via a tube inserted thru the stomach wall and into the small intestine with the gel C/L delivered close to the area in the small intestine where absorption of C/L into the capillaries is the maximum. drug companies luv patches, generic companies have to put in more resources and develop the skills to make a patch so greater chance no generic would be made, the brand name company can lower their price if needed. to repeat, drug companies have made a lot of patch systems for many different drugs, if the properties of the skin and l-dopa allowed enough l-dopa to pass thru the skin to allow a useful constant delivery we'd all be wearing small patches rather than the body length patches we would need.

Transdermal patch - Wikipedia
Positive Results for Levodopa/ Carbidopa ‘Pump Patch’ | Parkinson's Disease


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True
 

Years ago, and I mean, like a decade at least, we asked our neuro about a patch for sinemet or actually just levodopa. He said he thought they were working on it in Israel but the problem at that time was the test patches kept burning the skin-apparently it's caustic, and they were trying to figure out how to address that. Since it's been at least ten years since then, I would guess that they weren't able to get around that obstacle. My efforts to find out who and where this research might be being done have been frustratingly unsuccessful.

Stinks, because a patch would be so very much better than taking pills or having a hole in your abdomen.

Why don't they bind it to lysine in a pill?