Panama is the place to go for stem cell therapy -where science and blend
 

Applying medicine is an art because people respond uniquely to stimulus . This is where science struggles imho ..there are docs that are good at both....

Joe Rogan & Mel Gibson on Stem Cell Therapy - YouTube

Post Script : title of this thread was intended to say "Panama is the place to go for stem cell therapy - where science and art blend" but I d on't know how to edit it..

Wow, that was really interesting.

I noticed a longer version (just over 1 hour) which was also well worth watching.

Joe Rogan Experience #166 - Mel Gibson & Dr. Neil Riordan - YouTube

There was no mention of PD though, and from some of what was said in the final 10 minutes, I got the impression that they don't see PD as one of their targets.

I could be wrong, but , they may be "targeting" the individual (and) the disease..Einsteins words come t o mind about solving problems from a different perspective than that which they were "created".....also the saying that to approach a problem the same way over and again lays groundwork for insanity... :( Dr. Riordan comes very highly recommended.

If you like this you might also like Dr. Medici .. at www.straighttalk.cc - a rich resource of great articles...(and this youtube video) - one on stem cells which showed that active sympathetic nerve activity inhibits stem cell growth - (>> A Wiser Medicine: The Wisdom of Eastern Medicine – 368) which would explain failure of application of stem cell therapy by those who don't take into account a larger picture that embraces inherent contradictions.

Kind Regards,
Sharilyn

hows' your heart health?
 

Would be interesting to experiment to see if stem cell therapy for heart would help parkinsons sx....

This article may be of interest to members who are considering stem cell therapy Nine Things to Know About Stem Cell Treatments.

The focus of the first video was umbilical cord mesenchymal stem cells (MSCs), and their use in the treatment of conditions/diseases not including PD.

The focus of the following video is induced pluripotent stem cells (IPSCs), and their (future) use in the treatment of PD (mainly). The video is a recent interview with Dr. Jeanne Loring of Scripps Research Institute (8th June 2018, approx. 30 mins).

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Thanks jeffreyn.

I heard Dr Loring give a talk at a conference once; I was very impressed with her.

At 43+ minutes in reference was made to ALL chronic degenerative disease (your link to Joe Rogan /Mel Gibson longer video ) for (possibly creative??)application of (MSC) stem cells.

When I used the phrase "not including PD", I just meant that PD was not one of the conditions/diseases mentioned in the video.

I think you are right to suggest that MSCs might be of benefit in the treatment of PD.

My understanding of MSCs (from the video) is that they are found throughout the body, they modulate the immune system, decrease inflammation, and stimulate regeneration. They do not transform into other types of cell. Their influence occurs via the production of cytokines and growth factors.

Stem cells sourced from our own body verses cells sourced from another raises so many questions - more questions than answers but isn't it interesting that we have a way to optimize our own potential completely within us yet nature is also at the same time interdependent...building a more robust spacial semantic where both are true seems to be such a struggle.
:)

What if this more generalized stimulus could catalyze/engage the autonomic nerve system to repair what is needed?

What if this more gereneralized stimulus could catalyze/engage the autonomic nerve system to do the needed (specific)repair?

This review of MSCs may be of interest Human mesenchymal stem cells - current trends and future prospective.

Most of the work has come from animal models so may or may not be relevant to people.

There are some ongoing clinical trials but no results seem to be available yet.

Here is my two cents worth on (umbilical cord) mesenchymal stem cells (MSCs) and induced pluripotent stem cells (IPSCs).

There is a theory that chronic neuroinflammation in PD is a result of chronic inflammation in the gut. Assuming that this is correct, it is conceivable that MSCs (perhaps given intravenously) might be able to halt the inflammation in the gut, thereby possibly bringing to a halt the inflammation in the brain. This would be a form of neuroprotection, possibly halting/slowing the progression of the disease.

For those PwPs in more advanced stages of the disease, neuroprotection is not sufficient. What is required is neuroregeneration, possibly via new dopamine neurons made from IPSCs.

NB: I haven't read any of the papers on MSCs yet, so my view is likely to change!

The gut inflammation:PD link sounds plausible to me. Here is a discussion of it https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445611/.

I reckon that MSCs and IPSCs are well worth thinking about in this context

MSCs for PD - a chance to get involved ...
 

I found something interesting. There is actually a clinical trial underway in Texas that is focused on the use of bone-marrow-derived mesenchymal stem cells (delivered intravenously) for the treatment of PD. It is currently recruiting PwPs.

Allogeneic Bone Marrow-Derived Mesenchymal Stem Cell Therapy for Idiopathic Parkinson's Disease - Full Text View - ClinicalTrials.gov

NB: This trial is using bone-marrow-derived MSCs (i.e. not umbilical cord MSCs).

Hopefully it won't be too long before we see an MSCs-for-PD clinical trial that uses umbilical cord MSCs.

Young MSCs for PD!
 

jeffreyn wrote: "Hopefully it won't be too long before we see an MSCs-for-PD clinical trial that uses umbilical cord MSCs".

Not too long at all it seems! There are now TWO such trials.

The first one is in Jordan:
Use of Mesenchymal Stem Cells in Parkinson Disease (PD) - Full Text View - ClinicalTrials.gov

The second one is in China:
Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Parkinson's Disease - Full Text View - ClinicalTrials.gov

Aside:
I was thinking about "plasma fractions" (such as GRF6021 from Grifols/Alkahest), and it reminded me of this thread from last year about (umbilical-cord-derived) mesenchymal stem cells (MSCs).

As I wrote earlier in the thread: "My understanding of MSCs is that they are found throughout the body, they modulate the immune system, decrease inflammation, and stimulate regeneration. They do not [necessarily] transform into other types of cell. Their influence [potentially] occurs via the production of cytokines and growth factors."

Simplistically, it seems to me that with plasma fractions you assemble a collection of molecules (proteins) and then inject them, whereas with MSCs it's the MSCs that create the molecules (after they themselves have been injected)!

Preclinical research for the Texas MSCs-for-PD clinical trial
 

For anyone who may be interested, here is (some of?) the preclinical research underpinning the Texas MSCs-for-PD clinical trial.

(PDF) A Meta-Analysis of Mesenchymal Stem Cells in Animal Models of Parkinson’s Disease

Update on the Texas MSCs-for-PD clinical trial
 

From the recent AANAM 2019 conference (via PNT):

#AANAM 219 - Stem Cell Therapy for Parkinson's Safe, Improves Motor Function in Early Study

Thanks to RooJr for posting this link, in the following thread:

https://www.neurotalk.org/parkinson-...s-suggest.html