Non-opioid drug relieves pain in mice, targets immune cells
 

Only shown to work in mice so far, and of course most of these things don't pan out in the end. Still, it's another step toward understanding the pathology of PN and potential interventions.

From:
medicine.wustl.edu/news/targeting-immune-cells-provides-non-opioid-pain-relief-in-mice/

"Recently, a non-opioid, investigational drug called EMA401 has shown promise as a treatment for lingering nerve pain following shingles infection. While trying to understand how that drug helped control pain, the Washington University research team was surprised to find that it doesn't hit nerve cells; rather, it targets a receptor on immune cells. Their findings are published July 2 in The Journal of Neuroscience."

"Generally, scientists have the understanding that targets for treating pain must be within the nervous system. It turns out that the target here is not on nerve cells, but on immune cells called macrophages."

The Abstract of the paper that you referred to is here Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain | Journal of Neuroscience .

Thanks
 

Thank you!