Istradefylline, now FDA approved
My thanks to Iqbal at HU for pointing me at this news.
The FDA "has approved istradefylline (Nourianz, Kyowa Kirin) tablets as add-on treatment to levodopa/carbidopa in adults with Parkinson's disease (PD) experiencing "off" episodes. Istradefylline is a selective adenosine A2A receptor antagonist." [1] Istradefylline has been around for years. It was well covered in the early days of the forum, but nothing for the last 5 years. Efficacy for those concurrently taking L/C was: "The pooled analysis included 2719 treated patients (placebo, n=992; 20 mg/day, n=848; 40 mg/day, n=879). At week 12, OFF-hours/day with 20 and 40mg istradefylline was reduced (LS mean difference from placebo in reduction from baseline [95%CI], −0.38 [−0.61, −0.15] and −0.45 [−0.68, −0.22], respectively) long half-life (>60 h) At steady state, istradefylline exposure increased by 35% in the presence of Cyp3A4 inhibitors" [2] But, what really interests me is: "It is estimated that the caffeine intake from a cup of coffee would only lead to 20% occupation of A2A receptors" [3] So, a cup of coffee gives just a few minutes more "on" time. But, with the long half-life this is good quality time and it may be additive. References: [1] FDA OKs Istradefylline for Parkinson's Disease 'Off' Episodes [2] A Pooled Analysis for Eight Randomized Controlled Trials of Istradefylline, an Adenosine A2A Receptor Antagonist: Efficacy as Adjunct to Levodopa in Parkinson’s Disease (PD) (P3.8- 3 ) | Neurology [3] Client Request Error John |
All times are GMT -5. The time now is 06:16 AM. |
Powered by vBulletin Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
vBulletin Optimisation provided by
vB Optimise v2.7.1 (Lite) -
vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.