Levodopa: 6 doses/day associated with less dyskinesia
 

A recent paper by Lin and Laurano [1] reports that a daily regimen based on 6 doses per day of levodopa is associated with a lower incidence of dyskinesia, compared with taking approximately the same total amount of levodopa in only 3 or 4 doses.

They also write that:
"To further reduce the fluctuation of levodopa in blood levels, entacapone [a catechol-O-methyltransferase (COMT) inhibitor] was also prescribed to most of the patients".

I've had no dyskinesia (diagnosed 14 years ago) on a regimen of 5 x 75 mg Stalevo, 1 x 8 mg ropinirole, 1 x 1 mg rasagiline.

I also dynamically dose: taking a pill when I begin to feel that the previous dose is about to start to decline in its effectiveness.

Reference:

[1] "Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia"
Mark M. Lin, Robert Laureno
J Mov Disord > Volume 12(1); 2019
Less Pulsatile Levodopa Therapy (6 Doses Daily) Is Associated with a Reduced Incidence of Dyskinesia

John