2020 Clinical Trials Report
 

Here is the latest on all the PD clinical trials for PD this year. I am too discouraged to read the paper but if someone wants to pick through and see if there is any good news, go to it.



Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 22 - IOS Press



A recently published research report - conducted by Parkinson's research advocates and the research team at The Cure Parkinson's Trust (CPT) – presents an encouraging and useful overview of the current pipeline of agents being clinically tested for the treatment of Parkinson’s.
The investigators analysed a large number of clinical trials (145 studies were included in the analysis) - categorising them into the type of drug being tested and the stage of their clinical development - to highlight interesting trends in how the disease is being targeted and to stimulate discussion and engagement between the research and Parkinson’s patient communities. This report represents one of the first classifications and in-depth analysis of its kind in the Parkinson's clinical trials arena.

Summary of a Summary
 

For anyone who may be time challenged, here is my overview of an overview from the American Parkinson Disease Association!

Categories covered:
- Alpha-synuclein strategies – decreasing aggregation of alpha-synuclein:
--- Alpha-synuclein antibodies (passive immunity);
--- Alpha-synuclein vaccine (active immunity);
--- Molecules that block alpha-synuclein.
- Glucagon-like peptide-1 (GLP-1) agonist strategies – decreasing neuro-inflammation;
- Glucocerebrosidase (GBA) – enhancing the cell’s lysosomal system;
- LRRK2 strategies;
- c-Abl kinase strategies – decreasing oxidative stress.

The Future of Parkinson’s Disease Treatments | APDA

"For anyone who may be time challenged, here is my overview of an overview" of an overview: don't hold your breath.

I believe that anyone who has Parkinson's now is better off managing presently available and proven treatments.

John

Clarification
 

Agreed!

I realize now that my term "time challenged" can have other meanings. The meaning I intended was: "Anyone too busy to read the original article (or even the APDA overview article)".

2021 Clinical Trials Report
 

The 2021 version of the "clinical trials pipeline" document is now available.

If you don't have time to read the document, just have a look at Figure 1 - it's inspirational !

Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2021 Update - IOS Press

There is also a PNT article about the document.

Clinical Trials of Parkinson's Treatments Robust Despite COVID-19